2. Gene
  3. DUSP3 - dual specificity phosphatase 3 Gene

DUSP3 - dual specificity phosphatase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：双特异性磷酸酶 3

种属: Homo sapiens

同用名: VHR

基因 ID: 1845 | 基因类型: protein coding

关于 DUSP3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,766,125-43,778,977 (from NCBI)

This gene has 5 transcripts (splice variants), 90 orthologues and 30 paralogues. Ubiquitous expression in heart (RPKM 57.5), esophagus (RPKM 29.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。该基因定位于包含 BRCA1 位点的区域，该位点赋予乳腺癌和卵巢癌易感性。尽管 DUSP3 在乳腺和卵巢组织中均有表达，但乳腺癌家系和散发性肿瘤中的突变筛查结果为阴性，从而得出该基因不是 BRCA1 的结论。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian Cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast Cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

DUSP3 基因产物(1)

mRNA Protein Name
NM_004090.4 NP_004081.1 dual specificity protein phosphatase 3

DUSP3 蛋白结构

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (37 - 175)

  • 0
  • 100
  • 185 a.a.
蛋白主名 其他名称

dual specificity protein phosphatase 3

dual specificity protein phosphatase VHR

DUSP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DUSP3 P51452 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
种属内
DUSP3 P51452 MEOX1 Homo sapiens P50221
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DUSP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71150 DUSP3 Protein, Human (His) P51452 (S2-P185) ≥95%

DUSP3 抗体

目录号 产品名 应用 反应物种
HY-P80646 DUSP3 Antibody WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Vaccinia
Variola Major

Smallpox
Myoclonic Epilepsy Of Lafora

Lafora Disease

Epilepsy, Progressive Myoclonic 2b

EPM2

Melf

Epilepsy, Progressive Myoclonic 2a

Epm2a

Lafora'S Disease

Lafora Body Disease

Lbd

Epilepsy, Progressive Myoclonic, 2a

Lafora Progressive Myoclonic Epilepsy

Epilepsy Progressive Myoclonic 2

Lafora Body Disorder

Pme Type 2

Progressive Myoclonic Epilepsy Type 2

Progressive Myoclonus Epilepsy Type 2

Epilepsy, Progressive Myoclonic 2

Epm2b

Ld

Progressive Myoclonic Epilepsy 2

Progressive Myoclonic Epilepsy 2a

Progressive Myoclonic Epilepsy 2b

Progressive Myoclonic Epilepsy Lafora Type

Epilepsy, Myoclonic, Of Lafora
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Progressive Myoclonus Epilepsy

Pme

Progressive Myoclonic Epilepsy

Myoclonic Epilepsies, Progressive

Unverricht-Lundborg Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123846 MLS-0437605 Inhibitor 99.92% 否
HY-135457 JMS-053 ≥98.0% 否
HY-RS04064 DUSP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DUSP3 VGNC VGNC:72012
Canis familiaris DUSP3 VGNC VGNC:53236
Felis catus DUSP3 VGNC VGNC:98903
Bos taurus DUSP3 VGNC VGNC:28259
Rattus norvegicus DUSP3 RGD RGD:1560049
Mus musculus DUSP3 MGD MGI:1919599
Others DUSP3 NCBI
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