Kat2b - K(lysine) acetyltransferase 2B Gene

中文名称：K (赖氨酸) 乙酰转移酶2B

种属: Mus musculus

同用名: Pcaf; p/CAF; A930006P13Rik

关于 Kat2b

功能概要

该基因编码的蛋白可启动多种功能，包括 N-乙酰转移酶活性；细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶抑制剂活性；和转录共激活因子活性。参与内部肽基-赖氨酸乙酰化和细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶活性的负调节。作用于组蛋白 H3-K9 乙酰化上游或内部；糖异生的正向调节；和 RNA 聚合酶 II 对转录的正调控。位于几种细胞成分中，包括肌动球蛋白；动粒；和肌节。 ATAC 复合体的一部分。以多种结构表达，包括早期孕体；泌尿生殖系统；淋巴系统腺体；肝;和肺。与人 KAT2B（赖氨酸乙酰转移酶 2B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including N-acetyltransferase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and transcription coactivator activity. Involved in internal peptidyl-lysine acetylation and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of gluconeogenesis; and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including actomyosin; kinetochore; and sarcomere. Part of ATAC complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human KAT2B (lysine acetyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]