1. Gene
  2. Pdgfa - platelet derived growth factor, alpha Gene

Pdgfa - platelet derived growth factor, alpha Gene

种属: Mus musculus

同用名: PDGF-1

基因 ID: 18590 | 基因类型: protein coding

关于 Pdgfa

功能概要

Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development and embryonic lung development. Acts upstream of or within several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfa 基因产物(2)

mRNA Protein Name
NM_001363271.1 NP_001350200.1 platelet-derived growth factor subunit A isoform 2 precursor
NM_008808.4 NP_032834.1 platelet-derived growth factor subunit A isoform 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of or within angiogenesis IDA
IDA: 通过直接分析推断
12101409 MGI
acts upstream of or within animal organ morphogenesis IGI
IGI: 通过遗传相互作用推断
15361870 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
14522834 MGI
acts upstream of or within bone development IGI
IGI: 通过遗传相互作用推断
23938297 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
10331973 MGI
acts upstream of or within cell projection assembly IDA
IDA: 通过直接分析推断
12176888 MGI
acts upstream of or within digestive tract development IGI
IGI: 通过遗传相互作用推断
23938297 MGI
involved in digestive tract development IMP
IMP: 通过突变表型推断
10903171 MGI
involved in embryonic lung development IMP
IMP: 通过突变表型推断
9374392 MGI
acts upstream of or within hair follicle development IMP
IMP: 通过突变表型推断
10331973 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
11803579 MGI
involved in lung alveolus development IMP
IMP: 通过突变表型推断
9374392 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10331973 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: 通过突变表型推断
10331973 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
IMP: 通过突变表型推断
18559345 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11940581 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
10331973 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
19734317 MGI
located in microvillus IDA
IDA: 通过直接分析推断
12101409 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

platelet-derived growth factor subunit A

PDGF A-chain

PDGF subunit A

platelet-derived growth factor A-chain

platelet-derived growth factor alpha polypeptide

重组 Pdgfa 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7277 PDGF-AA Protein, Mouse P20033 (S87-T211) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdgfa NCBI NCBI:5154
Canis familiaris Pdgfa NCBI NCBI:491597