Pdgfrb - platelet derived growth factor receptor, beta polypeptide Gene

中文名称：血小板衍生生长因子受体， β 多肽

种属: Mus musculus

同用名: Pdgfr; CD140b; PDGFR-1

关于 Pdgfrb

功能概要

该基因编码的蛋白可启动血小板衍生生长因子激活受体活性和信号受体结合活性。参与多个过程，包括细胞内信号转导的正向调节；蛋白质磷酸化；和血管发育。作用于多个过程的上游或内部，包括动物器官发育；对神经酰胺的反应；和荷叶边组装。位于细胞表面；细胞质；和荷叶边。以多种结构表达，包括消化系统；胚外成分；泌尿生殖系统；神经系统;和感觉器官。用于研究基底神经节钙化；婴儿肌纤维瘤病;骨髓增生性肿瘤；和严重的非增殖性糖尿病视网膜病变。该基因的人类直系同源基因与基底神经节钙化有关；胶质母细胞瘤;婴儿肌纤维瘤病;骨髓增生性肿瘤（多发性）；和肾细胞癌。与人 PDGFRB（血小板衍生生长因子受体 β）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables platelet-derived growth factor-activated receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including animal organ development; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Apr 2022]