Enpp2 - ectonucleotide pyrophosphatase/phosphodiesterase 2 Gene

种属: Mus musculus

同用名: ATX; Npps2; Pdnp2; E-NPP 2; lysoPLD; PD-Ialpha

关于 Enpp2

功能概要

This gene encodes a member of the phosphodiesterase and nucleotide pyrophosphatase family of bifunctional Enzymes that hydrolize phosphodiester bonds of various nucleotides. The encoded protein undergoes proteolytic processing to generate a mature protein with lysophospholipase D activity, catalyzing the cleavage of the choline group from lysophosphatidylcholine to produce lysophosphatidic acid. This gene is expressed in numerous tissues and participates in neural development, obesity, inflammation and oncogenesis. A complete lack of the encoded protein in mice results in aberrant vascular and neuronal development leading to embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature protein. [provided by RefSeq, Sep 2015]