E2F5 - E2F transcription factor 5 Gene

中文名称：E2F 转录因子 5

种属: Homo sapiens

同用名: E2F-5

基因 ID: 1875 | 基因类型: protein coding

关于 E2F5

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,177,154-85,214,518 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 7 paralogues. Broad expression in lymph node (RPKM 12.6), thyroid (RPKM 6.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是 E2F 转录因子家族的成员。 E2F 家族在控制细胞周期和肿瘤抑制蛋白的作用中起着至关重要的作用，也是小 DNA 肿瘤病毒转化蛋白的靶标。 E2F 蛋白包含几个进化上保守的结构域，存在于该家族的大多数成员中。这些结构域包括 DNA 结合结构域、决定与分化调节转录因子蛋白 (DP) 相互作用的二聚化结构域、富含酸性氨基酸的反式激活结构域，以及嵌入反式激活结构域内的肿瘤抑制蛋白关联结构域。这种蛋白质被差异磷酸化，并在多种人体组织中表达。与其他家族成员相比，它对 E2F4 具有更高的身份。这种蛋白质和 E2F4 都与肿瘤抑制蛋白 p130 和 p107 相互作用，但不与 pRB 相互作用。可变剪接导致编码不同异构体的多个变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic Amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

E2F5 基因产物(3)

mRNA	Protein	Name
NM_001083588.2	NP_001077057.1	transcription factor E2F5 isoform 2
NM_001083589.2	NP_001077058.1	transcription factor E2F5 isoform 3
NM_001951.4	NP_001942.2	transcription factor E2F5 isoform 1

E2F5 蛋白结构

E2F_TDP

0
100
200
300
346 a.a.

蛋白主名

其他名称

transcription factor E2F5

E2F transcription factor 5, p130-binding

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Retinal Cancer

Malignant Neoplasm Of Retina	Retinal Neoplasms
Malignant Retinal Neoplasm	Malignant Tumor Of Retina
Neoplasm Of Retina	Retinal Tumor
Retinal Neoplasm	Cancer Of The Retina
Malignant Retinal Tumour	Malignant Tumour Of Retina
Primary Malignant Neoplasm Of Retina

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Ocular Cancer

Eye Neoplasm	Eye Carcinoma
Eye Cancer	Eye Neoplasms
Malignant Eye Neoplasm	Neoplasm Of Eye
Neoplasm Of Eye Proper	Ocular Tumor
Carcinoma Of Eye	Ocular Carcinoma
Malignant Tumor Of Eye

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Soft Palate Cancer

Malignant Tumor Of Soft Palate	Malignant Tumor Of The Soft Palate
Palate Cancer Soft Palate

Retinal Disease

Retinal Diseases	Retinal Disorder
Retinal Disorders

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04114	E2F5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	E2F5	MGD	MGI:105091
Macaca mulatta	E2F5	VGNC	VGNC:72026
Canis familiaris	E2F5	VGNC	VGNC:40167
Felis catus	E2F5	VGNC	VGNC:81648
Bos taurus	E2F5	VGNC	VGNC:28289
Rattus norvegicus	E2F5	RGD	RGD:621357

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

E2F5 - E2F transcription factor 5 Gene

关于 E2F5

功能概要

E2F5 基因产物(3)

E2F5 蛋白结构

关联疾病

直系同源

热门区域

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E2F5 - E2F transcription factor 5 Gene

关于 E2F5

功能概要

E2F5 基因产物(3)

E2F5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z