Prkcd - protein kinase C, delta Gene

中文名称：蛋白激酶 C， δ

种属: Mus musculus

同用名: Pkcd; PKC[d]; PKCdelta; D14Ertd420e

关于 Prkcd

功能概要

该基因编码的蛋白可启动胰岛素受体底物结合活性和蛋白激酶 C 活性。参与多个过程，包括细胞成分组织的负调节；胰岛素受体信号通路的负调控；和血小板聚集的负调节。作用于 B 细胞增殖的上游或内部；免疫球蛋白介导的免疫反应；和凋亡信号通路的正调控。位于多个细胞成分中，包括细胞-细胞连接；细胞质；和核基质。以多种结构表达，包括消化系统；中枢神经系统;早期胚胎；泌尿生殖系统；和心脏和心包。该基因的人类直系同源物与自身免疫性淋巴增生综合征 3 型有关；脂肪肝病；和高血压。与人 PRKCD（蛋白激酶 C δ）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Insulin Receptor substrate binding activity and protein kinase C activity. Involved in several processes, including negative regulation of cellular component organization; negative regulation of Insulin Receptor signaling pathway; and negative regulation of platelet aggregation. Acts upstream of or within B cell proliferation; immunoglobulin mediated immune response; and positive regulation of apoptotic signaling pathway. Located in several cellular components, including cell-cell junction; cytoplasm; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; fatty liver disease; and hypertension. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]