1. Gene
  2. PRKCD - protein kinase C delta Gene

PRKCD - protein kinase C delta Gene

中文名称:蛋白激酶 C delta

种属: Homo sapiens

同用名: MAY1; PKCD; ALPS3; CVID9; nPKC-delta

基因 ID: 5580 | 基因类型: protein coding

关于 PRKCD

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,161,209-53,192,717 (from NCBI)

This gene has 14 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质是丝氨酸和苏氨酸特异性蛋白激酶的蛋白激酶 C 家族的成员。编码的蛋白质被甘油二酯激活,既是肿瘤抑制因子又是细胞周期进程的正调节因子。此外,这种蛋白质可以正向或负向调节细胞凋亡。该基因的缺陷是自身免疫性淋巴增生综合征的一个原因。[RefSeq 提供,2017 年 8 月]

The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate Apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

PRKCD 基因产物(16)

mRNA Protein Name
XM_047448564.1 XP_047304520.1 protein kinase C delta type isoform X1
NM_001354679.2 NP_001341608.1 protein kinase C delta type isoform c
NM_001316327.2 NP_001303256.1 protein kinase C delta type isoform c
NM_001354680.2 NP_001341609.1 protein kinase C delta type isoform c
NM_212539.2 NP_997704.1 protein kinase C delta type isoform c
NM_001354676.2 NP_001341605.1 protein kinase C delta type isoform a
NM_006254.4 NP_006245.2 protein kinase C delta type isoform c
XR_007095706.1
NM_001354678.2 NP_001341607.1 protein kinase C delta type isoform b
NM_001316327.2 NP_001303256.1 protein kinase C delta type isoform c
NM_001354676.2 NP_001341605.1 protein kinase C delta type isoform a
NM_001354678.2 NP_001341607.1 protein kinase C delta type isoform b
NM_001354679.2 NP_001341608.1 protein kinase C delta type isoform c
NM_001354680.2 NP_001341609.1 protein kinase C delta type isoform c
NM_006254.4 NP_006245.2 protein kinase C delta type isoform c
NM_212539.2 NP_997704.1 protein kinase C delta type isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables diacylglycerol-dependent serine/threonine kinase activity EXP
EXP: 通过实验结果推断
12391145 GOA
enables enzyme activator activity IDA
IDA: 通过直接分析推断
16611985 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
18556656 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
16611985 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9139733 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
24008408 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
10713049 GOA
enables protein serine kinase activity IDA
IDA: 通过直接分析推断
17303575 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10770950 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
17938203 GOA
involved in activation of protein kinase activity IDA
IDA: 通过直接分析推断
10713049 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
10770950 GOA
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
24008408 GOA
involved in cellular response to UV IDA
IDA: 通过直接分析推断
17303575 GOA
involved in cellular response to angiotensin IDA
IDA: 通过直接分析推断
18285462 GOA
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
10713049 GOA
involved in cellular response to hydroperoxide IDA
IDA: 通过直接分析推断
19059439 GOA
involved in cellular senescence IMP
IMP: 通过突变表型推断
15282327 GOA
involved in negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
19279008 GOA
involved in negative regulation of glial cell apoptotic process IMP
IMP: 通过突变表型推断
15774464 GOA
involved in neutrophil activation IDA
IDA: 通过直接分析推断
10770950 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
18285462 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
10770950 GOA
involved in positive regulation of ceramide biosynthetic process IMP
IMP: 通过突变表型推断
19279011 GOA
involved in positive regulation of endodeoxyribonuclease activity IMP
IMP: 通过突变表型推断
19059439 GOA
involved in positive regulation of glucosylceramide catabolic process IMP
IMP: 通过突变表型推断
19279011 GOA
involved in positive regulation of phospholipid scramblase activity IMP
IMP: 通过突变表型推断
10770950 GOA
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
19059439 GOA
involved in positive regulation of sphingomyelin catabolic process IMP
IMP: 通过突变表型推断
19279011 GOA
involved in positive regulation of superoxide anion generation IMP
IMP: 通过突变表型推断
19801500 GOA
involved in post-translational protein modification IDA
IDA: 通过直接分析推断
19059439 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10713049 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
22554282 GOA
involved in regulation of ceramide biosynthetic process IDA
IDA: 通过直接分析推断
17303575 GOA
involved in termination of signal transduction IMP
IMP: 通过突变表型推断
19279008 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15632189 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10770950 GOA
located in endolysosome IDA
IDA: 通过直接分析推断
17303575 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15774464 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15632189 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10770950 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRKCD 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (159 - 209)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (231 - 282)

Pkinase

Pkinase: Protein kinase domain (351 - 603)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (623 - 669)

  • 0
  • 200
  • 400
  • 600
  • 676 a.a.
蛋白主名 其他名称

protein kinase C delta type

protein kinase C delta VIII

tyrosine-protein kinase PRKCD

PRKCD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRKCD Q05655 GAP43 Homo sapiens P17677
Anti Bait CoIP
9139733
Intra PRKCD Q05655 GAP43 Homo sapiens P17677
Protein Kinase Assay
9139733
Intra PRKCD Q05655 TP53 Homo sapiens P04637
Pull Down
16377624
Intra PRKCD Q05655 TP53 Homo sapiens P04637
Protein Kinase Assay
16377624
Intra PRKCD Q05655 TP53 Homo sapiens P04637
Anti Bait CoIP
16377624
Intra PRKCD Q05655 FYN Homo sapiens P06241
Protein Kinase Assay
10383400
Intra PRKCD Q05655 FYN Homo sapiens P06241
Anti Bait CoIP
12721299
Intra PRKCD Q05655 FYN Homo sapiens P06241
ELISA
10383400
Intra PRKCD Q05655 DIABLO Homo sapiens Q9NR28
Anti Bait CoIP
22465666
Intra PRKCD Q05655 TOP2A Homo sapiens P11388
Pull Down
16611985
Intra PRKCD Q05655 TOP2A Homo sapiens P11388
Anti Bait CoIP
16611985
Intra PRKCD Q05655 TOP2A Homo sapiens P11388
Anti Tag CoIP
16611985
Intra PRKCD Q05655 TOP2A Homo sapiens P11388
Protein Kinase Assay
16611985
Intra PRKCD Q05655 IL32 Homo sapiens P24001-2
Anti Bait CoIP
23814099
Intra PRKCD Q05655 IL32 Homo sapiens P24001-2
IF
24396867
Intra PRKCD Q05655 IL32 Homo sapiens C6GKH1
IF
24996056
Intra PRKCD Q05655 IL32 Homo sapiens C6GKH1
Anti Tag CoIP
24996056
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lymphoproliferative Syndrome 3

LPFS3

Cd70 Deficiency

Combined Immunodeficiency Due To Cd70 Deficiency

Cid Due To Cd70 Deficiency

Glioma
Diabetes Mellitus

Diabetes

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma

Corticotroph Adenoma

Corticotropinoma

Pituitary-Dependent Cushing'S Disease

Adrenal Gland Hyperfunction

Cushing Syndrome

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia

CMDD

Cmdj

Cmd

Autosomal Dominant Craniometaphyseal Dysplasia

Craniometaphyseal Dysplasia, Jackson Type

Craniometaphyseal Dysplasia Jackson Type

Autosomal Recessive Craniometaphyseal Dysplasia

Cmdr

Dysplasia, Craniometaphyseal, Autosomal Dominant

Craniometaphyseal Dysplasia, Autosomal Recessive Type

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Systemic Lupus Erythematosus 16

SLEB16

Autosomal Systemic Lupus Erythematosus

Autosomal Sle

Familial Sle

Familial Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic, Type 16

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD

Autoimmune Lymphoproliferative Syndrome Type 4

Alps4

Autoimmune Lymphoproliferative Syndrome, Type Iv

Ras-Associated Autoimmune Leukoproliferative Disease

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic

Alps Type 4

Alps Type Iv

Autoimmune Lymphoproliferative Syndrome Type Iv

Autoimmune Lymphoproliferative Syndrome 4

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency

B Cell Deficiencies

Immunoglobulin Heavy Chain Deletion

Humoral Immune Defect

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Acquired Hypogammaglobulinemia

Common Variable Immune Deficiency

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2

CPVT2

Vtsip

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Ventricular Tachycardia, Stress-Induced Polymorphic

Cvpt2

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10

SCA10

Spinocerebellar Ataxia-10

Ataxia, Spinocerebellar, Type 10

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3

Autoimmune Lymphoproliferative Syndrome Type 3

Cvid9

Immunodeficiency, Common Variable, 9, Formerly

Cvid9, Formerly

Autoimmune Lymphoproliferative Syndrome Type Iii

Common Variable Immunodeficiency 9

Autoimmune Lymphoproliferative Syndrome 3

Immunodeficiency, Common Variable, 9

Type 3 Autoimmune Lymphoproliferative Syndrome

Immunodeficiency, Variable, Common, Type 9

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PRKCD VGNC VGNC:33329
Canis familiaris PRKCD VGNC VGNC:44979
Mus musculus PRKCD MGD MGI:97598
Macaca mulatta PRKCD VGNC VGNC:76411
Rattus norvegicus PRKCD RGD RGD:67383
Felis catus PRKCD VGNC VGNC:69058
Others PRKCD NCBI