1. Gene
  2. Prkd1 - protein kinase D1 Gene

Prkd1 - protein kinase D1 Gene

中文名称:蛋白激酶 D1

种属: Mus musculus

同用名: PKD; PKD1; Pkcm; Prkcm; nPKC-D1; nPKC-mu

基因 ID: 18760 | 基因类型: protein coding

关于 Prkd1

Chromosome 12: 50,388,014-50,695,881 reverse strand.GRCm39:CM001005.3

This gene has 1 transcript (splice variant), 208 orthologues, 2 paralogues and is associated with 12 phenotypes. Ubiquitous expression in genital fat pad adult (RPKM 3.1), subcutaneous fat pad adult (RPKM 2.4) and 26 other tissues.

功能概要

预测该基因编码的蛋白具有相同的蛋白质结合活性和蛋白激酶 C 活性。参与多个过程,包括成骨细胞分化的正调节;蛋白质输入细胞核的正调节;和角质形成细胞增殖的调节。在将螯合的钙离子释放到胞质溶胶中的调节上游或调节内起作用。位于多个细胞成分中,包括细胞皮层;细胞-细胞连接;和跨高尔基网络。以多种结构表达,包括消化系统;脑;早期胚胎;泌尿生殖系统;和感觉器官。与人类 PRKD1(蛋白激酶 D1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable identical protein binding activity and protein kinase C activity. Involved in several processes, including positive regulation of osteoblast differentiation; positive regulation of protein import into nucleus; and regulation of keratinocyte proliferation. Acts upstream of or within regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including cell cortex; cell-cell junction; and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human PRKD1 (protein kinase D1). [provided by Alliance of Genome Resources, Apr 2022]

Prkd1 基因产物(4)

mRNA Protein Name
NM_001382816.1 NP_001369745.1 serine/threonine-protein kinase D1 isoform 4
NM_001382815.1 NP_001369744.1 serine/threonine-protein kinase D1 isoform 3
NM_001382814.1 NP_001369743.1 serine/threonine-protein kinase D1 isoform 2
NM_008858.4 NP_032884.2 serine/threonine-protein kinase D1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17485491 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
28716882 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
10882525 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
10882525 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10882525 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11239398 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10882525 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10882525 MGI
located in trans-Golgi network IDA
IDA: 通过直接分析推断
11239398 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Prkd1 蛋白结构

C1_PKD1_rpt1

C1_PKD1_rpt1: cd20839 (137 - 208)

C1_PKD1_rpt2

C1_PKD1_rpt2: cd20842 (242 - 335)

PH_PKD

PH_PKD: cd01239 (421 - 548)

STKc_PKD

STKc_PKD: cd14082 (584 - 843)

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  • 918 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase D1

protein kinase C mu type

protein kinase C, mu

protein kinase D

Prkd1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Prkd1 Q62101 ITGB3 Homo sapiens P05106
Anti Bait CoIP
17485491
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkd1 NCBI NCBI:5587