2. Gene
  3. Prkcz - protein kinase C, zeta Gene

Prkcz - protein kinase C, zeta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C，zeta

种属: Mus musculus

同用名: Pkcz; zetaPKC; aPKCzeta; nPKC-zeta

基因 ID: 18762 | 基因类型: protein coding

关于 Prkcz

Chromosome 4: 155,344,586-155,445,818 reverse strand.GRCm39:CM000997.3

This gene has 10 transcripts (splice variants), 205 orthologues, 9 paralogues and is associated with 22 phenotypes. Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与 T 辅助 2 细胞分化的正调节和细胞因子产生的正调节。作用于多个过程的上游或内部，包括神经元投射扩展；蛋白质定位于质膜；和蛋白质磷酸化。位于多个细胞成分中，包括轴突丘；髓鞘底部区域；和核。以多种结构表达，包括消化系统；脑;泌尿生殖系统；呼吸系统;和感觉器官。与人 PRKCZ（蛋白激酶 C zeta）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz 基因产物(3)

mRNA Protein Name
NM_001355178.1 NP_001342107.1 protein kinase C zeta type isoform c
NM_008860.3 NP_032886.2 protein kinase C zeta type isoform a
NM_001039079.2 NP_001034168.1 protein kinase C zeta type isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16792529 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
14730360 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
21131967 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
19668197 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
15882626 MGI
acts upstream of or within neuron projection extension IGI
IGI: 通过遗传相互作用推断
19668197 MGI
involved in positive regulation of T-helper 2 cell cytokine production IMP
IMP: 通过突变表型推断
15987782 MGI
involved in positive regulation of T-helper 2 cell differentiation IMP
IMP: 通过突变表型推断
15987782 MGI
involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
15987782 MGI
involved in positive regulation of interleukin-13 production IMP
IMP: 通过突变表型推断
15987782 MGI
involved in positive regulation of interleukin-4 production IMP
IMP: 通过突变表型推断
15987782 MGI
involved in positive regulation of interleukin-5 production IMP
IMP: 通过突变表型推断
15987782 MGI
acts upstream of or within protein localization to plasma membrane IMP
IMP: 通过突变表型推断
16455755 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
14730360 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical cortex IDA
IDA: 通过直接分析推断
15950600 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
20551175 MGI
located in axon hillock IDA
IDA: 通过直接分析推断
19668197 MGI
located in bicellular tight junction IDA
IDA: 通过直接分析推断
15775979 MGI
located in cell cortex IDA
IDA: 通过直接分析推断
15950600 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
10882525 MGI
located in microtubule organizing center IGI
IGI: 通过遗传相互作用推断
19668197 MGI
located in myelin sheath abaxonal region IDA
IDA: 通过直接分析推断
20237282 MGI
located in nuclear envelope IDA
IDA: 通过直接分析推断
10882525 MGI
located in nuclear matrix IDA
IDA: 通过直接分析推断
10882525 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10882525 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10882525 MGI
located in vesicle IDA
IDA: 通过直接分析推断
17313651 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkcz 蛋白结构

PB1_aPKC

PB1_aPKC: cd06404 (15 - 97)

C1

C1: cl00040 (128 - 182)

PKc_like

PKc_like: cl21453 (235 - 591)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
蛋白主名 其他名称

protein kinase C zeta type

atypical protein kinase C

protein kinase C zeta subspecies

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11141 PRKCZ Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11142 Prkcz Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11143 Prkcz Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcz NCBI NCBI:5590
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z