EDN2 - endothelin 2 Gene

中文名称：内皮素 2

种属: Homo sapiens

同用名: ET2; ET-2; PPET2

基因 ID: 1907 | 基因类型: protein coding

关于 EDN2

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,478,775-41,484,683 (from NCBI)

This gene has 5 transcripts (splice variants), 267 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 7.3), esophagus (RPKM 3.9) and 5 other tissues.

功能概要

该基因编码分泌性血管收缩肽的内皮素蛋白家族的成员。前原蛋白被加工成一种短的成熟形式，它作为启动细胞内信号事件的内皮素受体的配体发挥作用。该基因产物参与广泛的生物过程，例如高血压和排卵。该基因的表达改变与肿瘤发生有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 10 月]

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive Peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

EDN2 基因产物(2)

mRNA	Protein	Name
NM_001302269.2	NP_001289198.1	endothelin-2 isoform 2 preproprotein
NM_001956.5	NP_001947.1	endothelin-2 isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hormone activity	IDA IDA: 通过直接分析推断	2649896	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in artery smooth muscle contraction	IDA IDA: 通过直接分析推断	8982507	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: 通过直接分析推断	12207323	GOA
involved in macrophage activation	IDA IDA: 通过直接分析推断	12207323	GOA
involved in macrophage chemotaxis	IDA IDA: 通过直接分析推断	12207323	GOA
involved in neutrophil chemotaxis	IDA IDA: 通过直接分析推断	9696419	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: 通过直接分析推断	1917960	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	1917960	GOA
involved in positive regulation of heart rate	IDA IDA: 通过直接分析推断	2649896	GOA
involved in positive regulation of leukocyte chemotaxis	IDA IDA: 通过直接分析推断	9696419	GOA
involved in positive regulation of prostaglandin-endoperoxide synthase activity	IMP IMP: 通过突变表型推断	9492062	GOA
involved in prostaglandin biosynthetic process	IDA IDA: 通过直接分析推断	9492062	GOA
involved in regulation of systemic arterial blood pressure by endothelin	IDA IDA: 通过直接分析推断	2649896	GOA
involved in vasoconstriction	IDA IDA: 通过直接分析推断	2649896	GOA
involved in vein smooth muscle contraction	IDA IDA: 通过直接分析推断	8982507	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	15691296	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EDN2 蛋白结构

Endothelin

0
100
178 a.a.

蛋白主名

其他名称

endothelin-2

preproendothelin 2

关联疾病

疾病名称

别名

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Li-Fraumeni Syndrome 1

Lfs1

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04164	EDN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	EDN2	MGD	MGI:95284
Macaca mulatta	EDN2	VGNC	VGNC:72157
Rattus norvegicus	EDN2	RGD	RGD:2533
Canis familiaris	EDN2	VGNC	VGNC:40200
Bos taurus	EDN2	VGNC	VGNC:28328
Felis catus	EDN2	VGNC	VGNC:61727

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

EDN2 - endothelin 2 Gene

关于 EDN2

功能概要

EDN2 基因产物(2)

EDN2 蛋白结构

关联疾病

直系同源

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EDN2 - endothelin 2 Gene

关于 EDN2

功能概要

EDN2 基因产物(2)

EDN2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z