1. Gene
  2. Ptafr - platelet-activating factor receptor Gene

Ptafr - platelet-activating factor receptor Gene

中文名称:血小板活化因子受体

种属: Mus musculus

同用名: PAFR

基因 ID: 19204 | 基因类型: protein coding

关于 Ptafr

Chromosome 4: 132,291,378-132,309,994 forward strand.GRCm39:CM000997.3

This gene has 1 transcript (splice variant), 223 orthologues, 6 paralogues and is associated with 8 phenotypes. Broad expression in mammary gland adult (RPKM 12.2), subcutaneous fat pad adult (RPKM 7.6) and 16 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 1 蛋白家族的成员。编码的蛋白质与其磷脂配体、血小板活化因子 (PAF) 的结合可以调节炎症反应和疼痛感。该基因的纯合基因敲除小鼠表现出受损的过敏反应、对细菌感染的抵抗力以及与疼痛相关的行为减少。 [RefSeq 提供,2015 年 8 月]

This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to Bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]

Ptafr 基因产物(1)

mRNA Protein Name
NM_001081211.2 NP_001074680.1 platelet-activating factor receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipopolysaccharide binding IMP
IMP: 通过突变表型推断
9013981 MGI
enables lipopolysaccharide immune receptor activity IMP
IMP: 通过突变表型推断
9013981 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cytokine production IMP
IMP: 通过突变表型推断
14742561 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
14742561 MGI
acts upstream of or within inositol trisphosphate biosynthetic process IMP
IMP: 通过突变表型推断
9013981 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
9013981 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ptafr 蛋白结构

7tmA_PAFR

7tmA_PAFR: cd15147 (15 - 302)

7tmA_PAFR

7tmA_PAFR: cd15147 (15 - 42)

7tmA_PAFR

7tmA_PAFR: cd15147 (51 - 76)

7tmA_PAFR

7tmA_PAFR: cd15147 (89 - 119)

7tmA_PAFR

7tmA_PAFR: cd15147 (131 - 153)

7tmA_PAFR

7tmA_PAFR: cd15147 (182 - 211)

7tmA_PAFR

7tmA_PAFR: cd15147 (224 - 254)

7tmA_PAFR

7tmA_PAFR: cd15147 (270 - 295)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

platelet-activating factor receptor

PAF receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptafr NCBI NCBI:5724