PTAFR - platelet activating factor receptor Gene

中文名称：血小板活化因子受体

种属: Homo sapiens

同用名: PAFR

关于 PTAFR

功能概要

该基因编码血小板活化因子 (PAF) 的七次跨膜 G 蛋白偶联受体，该受体定位于细胞膜中的脂筏和/或细胞膜穴样内陷。 PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) 是一种磷脂，在致癌转化、肿瘤生长、血管生成、转移和促炎过程中起着重要作用。 PAF 与 PAF 受体 (PAFR) 的结合可刺激多种信号转导通路，包括磷脂酶 C、D、A2、丝裂原活化蛋白激酶 (MAPK) 和磷脂酰肌醇-钙第二信使系统。 PAFR 激活后，细胞迅速脱敏，这种难治性状态依赖于 PAFR 磷酸化、内化和下调。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including Phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]