2. Gene
  3. ADCY4 - adenylate cyclase 4 Gene

ADCY4 - adenylate cyclase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷酸环化酶 4

种属: Homo sapiens

同用名: AC4

基因 ID: 196883 | 基因类型: protein coding

关于 ADCY4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,318,359-24,335,071 (from NCBI)

This gene has 19 transcripts (splice variants), 1 gene allele, 181 orthologues and 17 paralogues. Broad expression in placenta (RPKM 14.4), fat (RPKM 11.6) and 23 other tissues.

功能概要

该基因编码腺苷酸环化酶家族的一个成员，腺苷酸环化酶是一种膜相关酶，可催化第二信使环磷酸腺苷 (cAMP) 的形成。小鼠研究表明，腺苷酸环化酶 4 以及腺苷酸环化酶 2 和 3 在嗅觉纤毛中表达，表明几种不同的腺苷酸环化酶可能与嗅觉受体偶联，并且可能存在多种受体介导的机制来产生 cAMP 信号。可变剪接导致转录物变异。[RefSeq 提供，2010 年 11 月]

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated Enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that Adenylate Cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ADCY4 基因产物(3)

mRNA Protein Name
NM_001198568.2 NP_001185497.1 adenylate cyclase type 4
NM_001198592.2 NP_001185521.1 adenylate cyclase type 4
NM_139247.4 NP_640340.2 adenylate cyclase type 4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17081159 GOA
enables protein kinase C binding IDA
IDA: 通过直接分析推断
17081159 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11549699 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADCY4 蛋白结构

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (265 - 423)

DUF1053

DUF1053: Domain of Unknown Function (DUF1053) (479 - 584)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (865 - 1063)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1077 a.a.
蛋白主名 其他名称

adenylate cyclase type 4

ATP pyrophosphate-lyase 4

ADCY4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADCY4 Q8NFM4 ESRRG Homo sapiens P62508-3
Y2H Prey Pooling
32296183
种属内
ADCY4 Q8NFM4 ESRRG Homo sapiens P62508-3
Y2H Array
32296183
种属内
ADCY4 Q8NFM4 C1orf50 Homo sapiens Q9BV19
Validated Y2H
32296183
种属内
ADCY4 Q8NFM4 C1orf50 Homo sapiens Q9BV19
Y2H Array
32296183
种属内
ADCY4 Q8NFM4 C1orf50 Homo sapiens Q9BV19
Y2H Prey Pooling
32296183
种属内
ADCY4 Q8NFM4 PPARG Homo sapiens P37231
Y2H Array
32296183
种属内
ADCY4 Q8NFM4 PPARG Homo sapiens P37231
Y2H Prey Pooling
32296183
种属内
ADCY4 Q8NFM4 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
种属内
ADCY4 Q8NFM4 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amelogenesis Imperfecta, Type Iiic

AI3C

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive

Amelogenesis Imperfecta Type 3c

Amelogenesis Imperfecta, Type 3c

Amelogenesis Imperfecta Type Iiic

Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3c
Angiostrongyliasis

A. Cantonensis Angiostrongyliasis
Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Gnathomiasis

Gnathostomiasis

Infectious Disease By Gnathostoma

Gnathostomosis

Wandering Swelling
Amelogenesis Imperfecta, Type Iv

AI4

Aihht

Amelogenesis Imperfecta Type 4

Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism

Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism

Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism

Amelogenesis Imperfecta 4

Ait

Amelogenesis Imperfecta 2 Hypocalcification Type

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iv

Amelogenesis Imperfecta With Taurodontism
Chronic Meningitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00330 ADCY4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADCY4 VGNC VGNC:110581
Mus musculus ADCY4 MGD MGI:99674
Bos taurus ADCY4 VGNC VGNC:25645
Rattus norvegicus ADCY4 RGD RGD:2034
Felis catus ADCY4 VGNC VGNC:59617
Canis familiaris ADCY4 VGNC VGNC:37621
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