2. Gene
  3. EIF5 - eukaryotic translation initiation factor 5 Gene

EIF5 - eukaryotic translation initiation factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 5

种属: Homo sapiens

同用名: EIF-5; EIF-5A

基因 ID: 1983 | 基因类型: protein coding

关于 EIF5

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:103,334,237-103,345,025 (from NCBI)

This gene has 21 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in bone marrow (RPKM 60.5), thyroid (RPKM 44.5) and 25 other tissues.

功能概要

真核翻译起始因子 5 (EIF5) 与 40S 起始复合物相互作用，促进结合 GTP 的水解，同时将 60S 核糖体亚基连接到 40S 起始复合物。由此产生的功能性 80S 核糖体起始复合物随后在肽基转移和链延长中具有活性 (Si 等人总结，1996 [PubMed 8663286]) 。[OMIM 提供，2010 年 5 月]

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

EIF5 基因产物(2)

mRNA Protein Name
NM_001969.5 NP_001960.2 eukaryotic translation initiation factor 5
NM_183004.5 NP_892116.2 eukaryotic translation initiation factor 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21745818 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of translational initiation IDA
IDA: 通过直接分析推断
22156057 GOA
involved in ribosome assembly IDA
IDA: 通过直接分析推断
10659855 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12426392 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
12426392 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF5 蛋白结构

eIF-5_eIF-2B

eIF-5_eIF-2B: Domain found in IF2B/IF5 (3 - 128)

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (308 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 5

EIF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Y2H Array
32296183
种属内
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
25416956
种属内
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
32296183
种属内
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75255 EIF5 Protein, Human (His) P55010 (M1-D150) ≥95%
HY-P700566 EIF5 Protein, Human (His-SUMO) P55010 (M1-I431) ≥95%

关联疾病

疾病名称 别名
Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111522 RK-9123016 Inhibitor 99.02% 否
HY-121722 Deoxyhypusine / 否
HY-RS04285 EIF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04286 EIF5A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04287 EIF5A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04288 EIF5B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-122039 Hypusine dihydrochloride / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EIF5 VGNC VGNC:28418
Felis catus EIF5 VGNC VGNC:61797
Rattus norvegicus EIF5 RGD RGD:619861
Macaca mulatta EIF5 VGNC VGNC:72197
Canis familiaris EIF5 VGNC VGNC:40292
Mus musculus EIF5 MGD MGI:95309
Others EIF5 NCBI
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