STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B Gene

中文名称：STT3 寡糖转移酶复合催化亚基 B

种属: Homo sapiens

同用名: SIMP; CDG1X; STT3-B

基因 ID: 201595 | 基因类型: protein coding

关于 STT3B

Cytogenetic location: 3p23 Genomic coordinates (GRCh38): 3:31,532,925-31,637,616 (from NCBI)

This gene has 7 transcripts (splice variants), 274 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 42.8), thyroid (RPKM 37.3) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白质复合物的催化亚基，可将寡糖转移到天冬酰胺残基上。该基因的缺陷是糖基化 Ix (CDG1X) 先天性障碍的一个原因。[RefSeq 提供，2014 年 6 月]

The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]

STT3B 基因产物(1)

mRNA	Protein	Name
NM_178862.3	NP_849193.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP IMP: 通过突变表型推断	19167329	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19167329	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	22607976	GOA
involved in co-translational protein modification	IMP IMP: 通过突变表型推断	19167329	GOA
involved in glycoprotein catabolic process	IMP IMP: 通过突变表型推断	22607976	GOA
involved in post-translational protein modification	IMP IMP: 通过突变表型推断	19167329	GOA
involved in protein N-linked glycosylation	IDA IDA: 通过直接分析推断	31831667	GOA
involved in protein N-linked glycosylation	IMP IMP: 通过突变表型推断	22467853	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: 通过突变表型推断	19167329	GOA
involved in response to unfolded protein	IMP IMP: 通过突变表型推断	19167329	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of oligosaccharyltransferase complex	IDA IDA: 通过直接分析推断	22467853	GOA
part of oligosaccharyltransferase complex	IPI IPI: 通过物理相互作用推断	31831667	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	28246125	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STT3B 蛋白结构

STT3

0
200
400
600
826 a.a.

蛋白主名

其他名称

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

STT3, subunit of the oligosaccharyltransferase complex, homolog B

STT3B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Crosslink	30021884
种属内	STT3B	Q8TCJ2	RPN1	Homo sapiens	P04843	Anti Tag CoIP	35271311
种属内	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
种属内	STT3B	Q8TCJ2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Congenital Disorder Of Glycosylation, Type Ix

CDG1X	Cdg Ix
Cdgix	Congenital Disorder Of Glycosylation 1x
Stt3b-Cdg	Cdg-Ix
Congenital Disorder Of Glycosylation Type Ix	Congenital Disorder Of Glycosylation Ix
Cdg Syndrome Type Ix	Carbohydrate Deficient Glycoprotein Syndrome Type Ix
Congenital Disorder Of Glycosylation Type 1x	Glycosylation, Congenital Disorder Of, Type Ix

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN	X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
Cid Due To Magt1 Deficiency	Combined Immunodeficiency Due To Magt1 Deficiency
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An	X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Louping Ill

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117383	NGI-1	Inhibitor	99.95%	否
HY-RS13971	STT3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	STT3B	MGD	MGI:1915542
Felis catus	STT3B	VGNC	VGNC:65804
Bos taurus	STT3B	VGNC	VGNC:35428
Macaca mulatta	STT3B	VGNC	VGNC:78245
Canis familiaris	STT3B	VGNC	VGNC:52904
Rattus norvegicus	STT3B	RGD	RGD:1311563

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B Gene

关于 STT3B

功能概要

STT3B 基因产物(1)

STT3B 蛋白结构

STT3B 蛋白互作信息

关联疾病

直系同源

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STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B Gene

关于 STT3B

功能概要

STT3B 基因产物(1)

STT3B 蛋白结构

STT3B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

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Q

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