Scn3a - sodium channel, voltage-gated, type III, alpha Gene

中文名称：钠通道，电压门控， II I 型， α

种属: Mus musculus

同用名: Gm1000; Nav1.3

关于 Scn3a

功能概要

预测该基因编码的蛋白可启动钙调蛋白结合活性；钠离子结合活性；和电压门控钠通道活性。预计参与多个过程，包括神经元动作电位；对拟除虫菊酯的反应；和钠离子跨膜转运。预计在离子跨膜转运和钠离子转运的调节上游或调节内起作用。位于细胞质和细胞膜中。在大脑皮层表达；心;坐骨神经;交感神经节;和端脑。该基因的人类直系同源基因与发育和癫痫性脑病 62 以及局灶性癫痫有关。与人类 SCN3A（钠电压门控通道 α 亚基 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Calmodulin binding activity; sodium ion binding activity; and voltage-gated Sodium Channel activity. Predicted to be involved in several processes, including neuronal action potential; response to pyrethroid; and sodium ion transmembrane transport. Predicted to act upstream of or within regulation of ion transmembrane transport and sodium ion transport. Located in cytoplasm and membrane. Is expressed in cerebral cortex; heart; sciatic nerve; sympathetic ganglion; and telencephalon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and focal epilepsy. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2022]