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  2. ENPEP - glutamyl aminopeptidase Gene

ENPEP - glutamyl aminopeptidase Gene

中文名称:谷氨酰氨肽酶

种属: Homo sapiens

同用名: APA; CD249; gp160

基因 ID: 2028 | 基因类型: protein coding

关于 ENPEP

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:110,476,155-110,565,285 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 132.9), kidney (RPKM 71.6) and 5 other tissues.

功能概要

ENPEP 基因编码谷氨酰氨基肽酶,一种具有细胞外锌结合结构域的 II 型整合膜蛋白。这种蛋白质可以通过切割血管紧张素 II 的 N 末端天冬氨酸来上调血压,并且可以调节血管形成并增强某些组织的肿瘤发生。与 ANPEP 和 DPP4 一起,ENPEP 被发现是导致 COVID-19 的冠状病毒 SARS-CoV-2 的候选共同受体。[RefSeq 提供,2020 年 4 月]

The ENPEP gene encodes glutamyl Aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

ENPEP 基因产物(4)

mRNA Protein Name
NM_001379611.1 NP_001366540.1 glutamyl aminopeptidase isoform 2
NM_001379612.1 NP_001366541.1 glutamyl aminopeptidase isoform 3
NM_001379613.1 NP_001366542.1 glutamyl aminopeptidase isoform 4
NM_001977.4 NP_001968.3 glutamyl aminopeptidase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
8244382 GOA
enables metalloaminopeptidase activity IDA
IDA: 通过直接分析推断
8346219 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell migration IDA
IDA: 通过直接分析推断
14998491 GOA
acts upstream of or within cell population proliferation IDA
IDA: 通过直接分析推断
14998491 GOA
involved in regulation of systemic arterial blood pressure by renin-angiotensin IDA
IDA: 通过直接分析推断
19608358 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
10692253 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ENPEP 蛋白结构

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (92 - 482)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (616 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 957 a.a.
蛋白主名 其他名称

glutamyl aminopeptidase

AP-A

重组 ENPEP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72824 Aminopeptidase A Protein, Human (sf9, His) Q07075/NP_001968.3 (R41-G957) ≥95%

关联疾病

疾病名称 别名
Choriocarcinoma

Chorioepithelioma

Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Crimean-Congo Hemorrhagic Fever

Crimean Hemorrhagic Fever

Cchf

Congo Hemorrhagic Fever

Hemorrhagic Fever, Crimean

Chf Congo Virus

Congo-Crimean Hemorrhagic Fever

Congo Fever

Hemorrhagic Fever Crimean-Congo

Cchf - [Crimean-Congo Haemorrhagic Fever]

Kara Mikh Typhoid Fever

Xīnjiāng Haemorrhagic Fever

Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome

Vas Deferens, Congenital Bilateral Aplasia Of

Congenital Bilateral Absence Of Vas Deferens

CBAVD

Cavd

Congenital Bilateral Aplasia Of Vas Deferens

Congenital Bilateral Absence Of The Vas Deferens

Congenital Bilateral Agenesis Of Vas Deferens

Absence Of Vas Deferens

Absent Vasa

Congenital Absence Of Vas Deferens

Congenital Aplasia Of Vas Deferens

Absent Vas Deferens

Vas Deferens, Congenital Bilateral Absence

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ENPEP VGNC VGNC:72221
Mus musculus ENPEP MGD MGI:106645
Rattus norvegicus ENPEP RGD RGD:621228
Felis catus ENPEP VGNC VGNC:61871
Canis familiaris ENPEP VGNC VGNC:40373
Bos taurus ENPEP VGNC VGNC:28503
Others ENPEP NCBI