1. Gene
  2. Msr1 - macrophage scavenger receptor 1 Gene

Msr1 - macrophage scavenger receptor 1 Gene

种属: Mus musculus

同用名: MSR; SR-A; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1

基因 ID: 20288 | 基因类型: protein coding

关于 Msr1

功能概要

Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of Cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; limb; neural tube; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate Cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Msr1 基因产物(2)

mRNA Protein Name
NM_001113326.2 NP_001106797.2 macrophage scavenger receptor types I and II isoform b
NM_031195.3 NP_112472.3 macrophage scavenger receptor types I and II isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IGI
IGI: 通过遗传相互作用推断
11240025 MGI
enables cargo receptor activity IGI
IGI: 通过遗传相互作用推断
22438044 MGI
enables low-density lipoprotein particle binding IMP
IMP: 通过突变表型推断
12376530 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
22438044 MGI
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
11240025 MGI
involved in cholesterol transport IMP
IMP: 通过突变表型推断
12376530 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
17148552 MGI
acts upstream of or within lipoprotein transport IMP
IMP: 通过突变表型推断
17148552 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
11240025 MGI
involved in phagocytosis, engulfment IGI
IGI: 通过遗传相互作用推断
22438044 MGI
involved in plasma lipoprotein particle clearance IMP
IMP: 通过突变表型推断
12376530 MGI
involved in positive regulation of cholesterol storage IMP
IMP: 通过突变表型推断
12376530 MGI
involved in positive regulation of macrophage derived foam cell differentiation IGI
IGI: 通过遗传相互作用推断
12376530 MGI
involved in receptor-mediated endocytosis IGI
IGI: 通过遗传相互作用推断
22438044 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IMP
IMP: 通过突变表型推断
11240025 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

macrophage scavenger receptor types I and II

macrophage acetylated LDL receptor I and II

scavenger receptor type A

重组 Msr1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76782 CD204/MSR1 Protein, Mouse (HEK293, His) AAH03814.1 (W83-V354) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Msr1 NCBI NCBI:4481
Rattus norvegicus Msr1 NCBI NCBI:498638
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