2. Gene
  3. Serpine2 - serine (or cysteine) peptidase inhibitor, clade E, member 2 Gene

Serpine2 - serine (or cysteine) peptidase inhibitor, clade E, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PI7; PI-7; PN-1; Spi4; PAI-1; B230326M24Rik

基因 ID: 20720 | 基因类型: protein coding

关于 Serpine2

功能概要

Enables serine-type endopeptidase inhibitor activity and signaling receptor binding activity. Involved in negative regulation of plasminogen activation and negative regulation of platelet aggregation. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; negative regulation of protein metabolic process; and negative regulation of signal transduction. Located in extracellular region and neuromuscular junction. Is expressed in several structures, including alimentary system; central nervous system; limb; musculoskeletal system; and reproductive system. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Apr 2022]

Serpine2 基因产物(1)

mRNA Protein Name
NM_009255.4 NP_033281.1 glia-derived nexin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables serine-type endopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
11248026 MGI
enables signaling receptor binding IGI
IGI: 通过遗传相互作用推断
17409116 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blood coagulation IMP
IMP: 通过突变表型推断
19855083 MGI
acts upstream of or within cerebellar granular layer morphogenesis IMP
IMP: 通过突变表型推断
17409116 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception IMP
IMP: 通过突变表型推断
15509762 MGI
acts upstream of or within innervation IMP
IMP: 通过突变表型推断
17409231 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: 通过突变表型推断
9169529 MGI
acts upstream of or within mating plug formation IMP
IMP: 通过突变表型推断
11248026 MGI
acts upstream of or within negative regulation of cell growth IGI
IGI: 通过遗传相互作用推断
18398001 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18398001 MGI
acts upstream of or within negative regulation of peptidase activity IMP
IMP: 通过突变表型推断
15509762 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
18398001 MGI
involved in negative regulation of plasminogen activation IMP
IMP: 通过突变表型推断
19855083 MGI
acts upstream of or within negative regulation of platelet activation IMP
IMP: 通过突变表型推断
19855083 MGI
involved in negative regulation of platelet activation IMP
IMP: 通过突变表型推断
19855083 MGI
involved in negative regulation of platelet aggregation IMP
IMP: 通过突变表型推断
19855083 MGI
acts upstream of or within negative regulation of protein catabolic process IMP
IMP: 通过突变表型推断
15509762 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
17409116 MGI
acts upstream of or within negative regulation of sodium ion transport IGI
IGI: 通过遗传相互作用推断
16941024 MGI
acts upstream of or within negative regulation of sodium ion transport IMP
IMP: 通过突变表型推断
16941024 MGI
acts upstream of platelet activation IMP
IMP: 通过突变表型推断
19855083 MGI
acts upstream of protein catabolic process IMP
IMP: 通过突变表型推断
15509762 MGI
acts upstream of or within regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
15509762 MGI
acts upstream of or within regulation of timing of cell differentiation IMP
IMP: 通过突变表型推断
17409116 MGI
acts upstream of or within response to wounding IMP
IMP: 通过突变表型推断
17409231 MGI
acts upstream of or within secretion by cell IMP
IMP: 通过突变表型推断
16319172 MGI
acts upstream of or within secretory granule organization IMP
IMP: 通过突变表型推断
16319172 MGI
acts upstream of or within seminal vesicle epithelium development IMP
IMP: 通过突变表型推断
11248026 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
2037625 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
2037625 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glia-derived nexin

GDN

peptidase inhibitor 7

protease nexin 1

protease nexin I

serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

serine (or cysteine) proteinase inhibitor, clade E, member 2

serine protease-inh

重组 Serpine2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71294 Serpin E2 Protein, Mouse (HEK293, His) Q07235 (S20-P397) ≥95%
HY-P71294Y Serpin E2 Protein, Mouse (HEK293, His, solution) Q07235 (S20-P397) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12723 SERPINE2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Serpine2 NCBI NCBI:5270
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