SERPINE2 - serpin family E member 2 Gene

中文名称：serpin 家族 E 成员 2

种属: Homo sapiens

同用名: GDN; PI7; PN1; PNI; PI-7; PN-1; GDNPF

基因 ID: 5270 | 基因类型: protein coding

关于 SERPINE2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:223,975,045-224,039,286 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 36 paralogues. Biased expression in placenta (RPKM 298.6), brain (RPKM 61.2) and 6 other tissues.

功能概要

该基因编码 serpin 蛋白家族的成员，这是一组抑制丝氨酸蛋白酶的蛋白质。凝血酶、尿激酶、纤溶酶和胰蛋白酶属于该家族成员可以抑制的蛋白酶。该基因是慢性阻塞性肺疾病和肺气肿的易感基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINE2 基因产物(3)

mRNA	Protein	Name
NM_001136528.2	NP_001130000.1	glia-derived nexin isoform b precursor
NM_001136530.1	NP_001130002.1	glia-derived nexin isoform c precursor
NM_006216.4	NP_006207.1	glia-derived nexin isoform a precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glycosaminoglycan binding	IDA IDA: 通过直接分析推断	19855083	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	1939253	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	3279057	GOA
enables serine-type endopeptidase inhibitor activity	IDA IDA: 通过直接分析推断	3997857	GOA
enables serine-type endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	19855083	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	17379830	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of blood coagulation	IDA IDA: 通过直接分析推断	17379830	GOA
involved in negative regulation of plasminogen activation	IMP IMP: 通过突变表型推断	19855083	GOA
involved in negative regulation of proteolysis	IDA IDA: 通过直接分析推断	3997857	GOA
involved in positive regulation of astrocyte differentiation	IDA IDA: 通过直接分析推断	1691280	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in collagen-containing extracellular matrix	IDA IDA: 通过直接分析推断	3279057	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19855083	GOA
located in extracellular region	IDA IDA: 通过直接分析推断	3997857	GOA
located in platelet alpha granule	IDA IDA: 通过直接分析推断	19855083	GOA
located in platelet alpha granule	IMP IMP: 通过突变表型推断	19855083	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINE2 蛋白结构

Serpin

0
100
200
300
398 a.a.

蛋白主名

其他名称

glia-derived nexin

glial-derived neurite promoting factor

SERPINE2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
种属内	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
种属内	SERPINE2	P07093	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINE2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71085	Serpin E2 Protein, Human (HEK293, His)	P07093-2 (S20-P397)	≥95%

关联疾病

疾病名称

别名

Ciliary Dyskinesia, Primary, 27

Primary Ciliary Dyskinesia 27	CILD27
Ciliary Dyskinesia, Primary, 27, Without Situs Inversus	Primary Ciliary Dyskinesia 27 Without Situs Inversus
Primary Ciliary Dyskinesia 27 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, 27

Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30	CILD30
Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 30 Without Situs Inversus
Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus	Dyskinesia, Ciliary, Primary, Type 30

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Kartagener Syndrome

Kartagener'S Syndrome

Ciliary Dyskinesia, Primary, 1

CILD1	Pcd
Primary Ciliary Dyskinesia 1	Kartagener Syndrome
Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	Immotile Cilia Syndrome
Ics	Polynesian Bronchiectasis
Primary Ciliary Dyskinesia 1 With Or Without Situs Inversus	Ics1
Immotile Cilia Syndrome 1	Primary Ciliary Dyskinesia
KTGS	Dextrocardia-Bronchiectasis-Sinusitis Syndrome
Immotile Cilia Syndrome Kartagener Type	Primary Ciliary Dyskinesia Kartagener Type
Siewert Syndrome	Immotile Cilia
Dyskinesia, Ciliary, Primary, Type 1	Ciliary Motility Disorders

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12723	SERPINE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SERPINE2	VGNC	VGNC:68839
Macaca mulatta	SERPINE2	VGNC	VGNC:77369
Canis familiaris	SERPINE2	VGNC	VGNC:46037
Mus musculus	SERPINE2	MGD	MGI:101780
Bos taurus	SERPINE2	VGNC	VGNC:56144
Rattus norvegicus	SERPINE2	RGD	RGD:3748
Others	SERPINE2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SERPINE2 - serpin family E member 2 Gene

关于 SERPINE2

功能概要

SERPINE2 基因产物(3)

SERPINE2 蛋白结构

SERPINE2 蛋白互作信息

重组 SERPINE2 蛋白

关联疾病

直系同源

热门区域

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SERPINE2 - serpin family E member 2 Gene

关于 SERPINE2

功能概要

SERPINE2 基因产物(3)

SERPINE2 蛋白结构

SERPINE2 蛋白互作信息

重组 SERPINE2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z