2. Gene
  3. Spn - sialophorin Gene

Spn - sialophorin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cd43; Ly48; Galgp; Ly-48; A630014B01Rik

基因 ID: 20737 | 基因类型: protein coding

关于 Spn

功能概要

Enables heat shock protein binding activity. Involved in leukocyte tethering or rolling and positive regulation of T cell migration. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; regulation of T cell activation; and regulation of defense response. Located in basement membrane; external side of plasma membrane; and uropod. Is integral component of plasma membrane. Orthologous to human SPN (sialophorin). [provided by Alliance of Genome Resources, Apr 2022]

Spn 基因产物(2)

mRNA Protein Name
NM_001037810.2 NP_001032899.1 leukosialin precursor
NM_009259.5 NP_033285.1 leukosialin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
20633027 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11238599 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell costimulation IDA
IDA: 通过直接分析推断
7790813 MGI
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
11380685 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
10429671 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
7790813 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
10899905 MGI
involved in leukocyte tethering or rolling IMP
IMP: 通过突变表型推断
26700769 MGI
acts upstream of or within negative regulation of T cell activation IMP
IMP: 通过突变表型推断
9645617 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
7566153 MGI
involved in negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
17638845 MGI
acts upstream of or within negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
11937524 MGI
acts upstream of or within negative regulation of cell adhesion IMP
IMP: 通过突变表型推断
7566153 MGI
acts upstream of or within negative regulation of type IV hypersensitivity IMP
IMP: 通过突变表型推断
9645617 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
10429671 MGI
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
17638845 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
7790813 MGI
acts upstream of or within positive regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
20360400 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
10899905 MGI
acts upstream of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
20360400 MGI
involved in regulation of T cell migration IMP
IMP: 通过突变表型推断
21289089 MGI
acts upstream of or within regulation of defense response to virus IMP
IMP: 通过突变表型推断
7566153 MGI
acts upstream of or within regulation of immune response IMP
IMP: 通过突变表型推断
7566153 MGI
acts upstream of or within response to protozoan IDA
IDA: 通过直接分析推断
11994475 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
7514104 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7477353 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11728336 MGI
located in uropod IDA
IDA: 通过直接分析推断
11728336 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

leukosialin

3E8 antigen

B-cell differentiation antigen LP-3

leukocyte sialoglycoprotein

lymphocyte antigen 48

重组 Spn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75404 CD43 Protein, Mouse (HEK293, Fc) P15702 (D20-G248) ≥95%
HY-P78258 CD43 Protein, Mouse (HEK293, His) P15702 (D20-G248) ≥95%

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-107434 Molindone Antagonist / 否
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149004 SLF1081851 Inhibitor 98.11% 否
HY-150254A SLB1122168 formic Inhibitor 99.91% 否
HY-162655 SLF80821178 99.70% 否
HY-150254 SLB1122168 Inhibitor / 否
HY-149004A SLF1081851 TFA Inhibitor / 否
HY-149004B SLF1081851 hydrochloride / 否
HY-156408 Spns2-IN-1 Inhibitor / 否
HY-162655A SLF80821178 hydrochloride Inhibitor / 否
HY-162996 Spns2-IN-2 Inhibitor / 否
HY-E70039 alpha-2-3,6,8-Sialidosidase (SpNanA) / 否
HY-P10312 SPN009 Agonist / 否
HY-RS13689 SPN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13691 SPNS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13692 SPNS3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-107434S Molindone-d8 Inhibitor 99.2% 否
HY-12450 Lomofungin Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spn NCBI NCBI:6693
Macaca fascicularis Spn NCBI NCBI:102147271
Rattus norvegicus Spn NCBI NCBI:24796
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