2. Gene
  3. Stk11 - serine/threonine kinase 11 Gene

Stk11 - serine/threonine kinase 11 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lkb1; Par-4

基因 ID: 20869 | 基因类型: protein coding

关于 Stk11

功能概要

This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, Apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]

Stk11 基因产物(3)

mRNA Protein Name
NM_001301853.2 NP_001288782.1 serine/threonine-protein kinase STK11 isoform S
NM_001301854.2 NP_001288783.1 serine/threonine-protein kinase STK11 isoform 3
NM_011492.5 NP_035622.1 serine/threonine-protein kinase STK11 isoform L
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables LRR domain binding IPI
IPI: 通过物理相互作用推断
11741830 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17482548 MGI
enables protein kinase activator activity IDA
IDA: 通过直接分析推断
17482548 MGI
enables protein kinase activator activity IMP
IMP: 通过突变表型推断
16308421 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11853558 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
16308421 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
25329316 MGI
acts upstream of or within Golgi localization IMP
IMP: 通过突变表型推断
21111240 MGI
acts upstream of or within T cell receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
21487392 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
21487392 MGI
acts upstream of axonogenesis IGI
IGI: 通过遗传相互作用推断
21111240 MGI
involved in axonogenesis IMP
IMP: 通过突变表型推断
17482548 MGI
involved in cellular response to UV-B IDA
IDA: 通过直接分析推断
25329316 MGI
acts upstream of or within dendrite extension IMP
IMP: 通过突变表型推断
24367100 MGI
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: 通过突变表型推断
18381428 MGI
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
17482548 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
16308421 MGI
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
11297520 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
25329316 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
27461402 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: 通过突变表型推断
18381428 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: 通过遗传相互作用推断
21111240 MGI
acts upstream of or within positive regulation of protein localization to nucleus IMP
IMP: 通过突变表型推断
24768298 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
18311138 MGI
involved in positive regulation of vesicle transport along microtubule IMP
IMP: 通过突变表型推断
24643070 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: 通过突变表型推断
21487392 MGI
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11853558 MGI
acts upstream of protein localization to nucleus IMP
IMP: 通过突变表型推断
24768298 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
25329316 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
24768298 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
18381428 MGI
involved in regulation of cell growth IDA
IDA: 通过直接分析推断
11853558 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
24367100 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
18381428 MGI
involved in response to ionizing radiation IDA
IDA: 通过直接分析推断
12234250 MGI
involved in spermatid development IMP
IMP: 通过突变表型推断
18774945 MGI
acts upstream of or within tissue homeostasis IMP
IMP: 通过突变表型推断
18381428 MGI
involved in vasculature development IMP
IMP: 通过突变表型推断
11509733 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10400995 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11297520 MGI
located in membrane IDA
IDA: 通过直接分析推断
11297520 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10400995 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine/threonine-protein kinase STK11

liver kinase B1 homolog

serine/threonine-protein kinase 11

serine/threonine-protein kinase LKB1

Stk11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Stk11 Q9WTK7 PRKAA2 Homo sapiens P54646
Anti Tag CoIP
19274086
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153358 TNG260 Inhibitor 99.91% 否
HY-N6904 Crocetin monomethyl ester Inhibitor 98.44% 否
HY-RS13921 STK11 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13922 STK11IP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-153358A (S)-TNG260 98.84% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stk11 NCBI NCBI:6794
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