Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box Gene

种属: Mus musculus

同用名: Tcf4; TCF4B; TCF4E; Tcf-4

基因 ID: 21416 | 基因类型: protein coding

关于 Tcf7l2

功能概要

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of Insulin secretion; regulation of transcription, DNA-templated; and response to glucose. Acts upstream of or within several processes, including animal organ development; negative regulation of cellular response to growth factor stimulus; and regulation of cellular biosynthetic process. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate Cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Tcf7l2 基因产物(31)

mRNA	Protein	Name
NM_001142918.2	NP_001136390.1	transcription factor 7-like 2 isoform 1
NM_001142919.2	NP_001136391.1	transcription factor 7-like 2 isoform 2
NM_001142920.2	NP_001136392.1	transcription factor 7-like 2 isoform 4
NM_001142921.2	NP_001136393.1	transcription factor 7-like 2 isoform 5
NM_001142922.2	NP_001136394.1	transcription factor 7-like 2 isoform 6
NM_001142923.2	NP_001136395.1	transcription factor 7-like 2 isoform 7
NM_001142924.2	NP_001136396.1	transcription factor 7-like 2 isoform 8
NM_001331135.1	NP_001318064.1	transcription factor 7-like 2 isoform 9
NM_001331136.1	NP_001318065.1	transcription factor 7-like 2 isoform 10
NM_001331137.1	NP_001318066.1	transcription factor 7-like 2 isoform 11
NM_001331138.1	NP_001318067.1	transcription factor 7-like 2 isoform 12
NM_001331139.1	NP_001318068.1	transcription factor 7-like 2 isoform 13
NM_001331140.1	NP_001318069.1	transcription factor 7-like 2 isoform 14
NM_001331141.1	NP_001318070.1	transcription factor 7-like 2 isoform 15
NM_001331142.1	NP_001318071.1	transcription factor 7-like 2 isoform 16
NM_001331143.1	NP_001318072.1	transcription factor 7-like 2 isoform 17
NM_001331144.1	NP_001318073.1	transcription factor 7-like 2 isoform 18
NM_001331145.1	NP_001318074.1	transcription factor 7-like 2 isoform 19
NM_001331146.1	NP_001318075.1	transcription factor 7-like 2 isoform 20
NM_001331147.1	NP_001318076.1	transcription factor 7-like 2 isoform 21
NM_001331148.1	NP_001318077.1	transcription factor 7-like 2 isoform 22
NM_001331149.1	NP_001318078.1	transcription factor 7-like 2 isoform 23
NM_001331150.1	NP_001318079.1	transcription factor 7-like 2 isoform 24
NM_001412695.1	NP_001399624.1	transcription factor 7-like 2 isoform 10
NM_001412705.1	NP_001399634.1	transcription factor 7-like 2 isoform 25
NM_001412706.1	NP_001399635.1	transcription factor 7-like 2 isoform 26
NM_001412707.1	NP_001399636.1	transcription factor 7-like 2 isoform 27
NM_001412708.1	NP_001399637.1	transcription factor 7-like 2 isoform 28
NM_001412710.1	NP_001399639.1	transcription factor 7-like 2 isoform 29
NM_001412711.1	NP_001399640.1	transcription factor 7-like 2 isoform 5
NM_009333.4	NP_033359.2	transcription factor 7-like 2 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	20044351	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	20044351	MGI
enables beta-catenin binding	IDA IDA: 通过直接分析推断	9784592	MGI
enables beta-catenin binding	IPI IPI: 通过物理相互作用推断	9488439	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	17727834	MGI
enables chromatin binding	IGI IGI: 通过遗传相互作用推断	23824574	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	15102471	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9488439	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	20044351	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of BMP signaling pathway	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within bone mineralization	IGI IGI: 通过遗传相互作用推断	19213727	MGI
involved in canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	9488439	MGI
involved in canonical Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	17699607	MGI
involved in canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	10937998	MGI
acts upstream of or within cellular response to starvation	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IGI IGI: 通过遗传相互作用推断	15057272	MGI
acts upstream of or within embryonic genitalia morphogenesis	IGI IGI: 通过遗传相互作用推断	15057272	MGI
acts upstream of or within embryonic hindgut morphogenesis	IGI IGI: 通过遗传相互作用推断	15057272	MGI
acts upstream of epithelial cell proliferation	IMP IMP: 通过突变表型推断	19251639	MGI
acts upstream of or within face morphogenesis	IGI IGI: 通过遗传相互作用推断	17699607	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within glucose homeostasis	IMP IMP: 通过突变表型推断	23028378	MGI
acts upstream of or within glucose metabolic process	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within glycogen metabolic process	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within in utero embryonic development	IMP IMP: 通过突变表型推断	27996060	MGI
acts upstream of or within insulin metabolic process	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within intracellular glucose homeostasis	IMP IMP: 通过突变表型推断	23028378	MGI
acts upstream of or within multicellular organism growth	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within myoblast fate commitment	IMP IMP: 通过突变表型推断	10937998	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: 通过突变表型推断	10937998	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within negative regulation of organ growth	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within neural tube development	IGI IGI: 通过遗传相互作用推断	15057272	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: 通过遗传相互作用推断	17699607	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: 通过突变表型推断	19741146	MGI
acts upstream of organ growth	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within pituitary gland development	IMP IMP: 通过突变表型推断	17919533	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19168596	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	17919533	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	19251639	MGI
acts upstream of or within positive regulation of gluconeogenesis	IMP IMP: 通过突变表型推断	23260145	MGI
involved in positive regulation of insulin secretion	IMP IMP: 通过突变表型推断	19168596	MGI
acts upstream of or within positive regulation of lipid biosynthetic process	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	20044351	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21335239	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15778706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within post-embryonic development	IMP IMP: 通过突变表型推断	23260145	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12861022	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: 通过突变表型推断	23028378	MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: 通过突变表型推断	19168596	MGI
acts upstream of or within regulation of myelination	IMP IMP: 通过突变表型推断	19503085	MGI
acts upstream of or within regulation of oligodendrocyte differentiation	IMP IMP: 通过突变表型推断	19503085	MGI
acts upstream of or within regulation of skeletal muscle tissue development	IMP IMP: 通过突变表型推断	21177349	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	19168596	MGI
involved in response to glucose	IMP IMP: 通过突变表型推断	19168596	MGI
acts upstream of or within secretory granule localization	IMP IMP: 通过突变表型推断	19168596	MGI
acts upstream of or within skin development	IGI IGI: 通过遗传相互作用推断	19718027	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: 通过遗传相互作用推断	19718027	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: 通过突变表型推断	9697701	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of catenin-TCF7L2 complex	IDA IDA: 通过直接分析推断	9488439	MGI
located in cytosol	IDA IDA: 通过直接分析推断	15578569	MGI
located in nucleus	IDA IDA: 通过直接分析推断	9697701	MGI
part of transcription regulator complex	IDA IDA: 通过直接分析推断	12861022	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transcription factor 7-like 2

HMG box transcription factor 4	HMG box transcription factor TCF7L2
T-cell-specific transcription factor 4

Tcf7l2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Tcf7l2	Q924A0	Hic1	Mus musculus	Q9R1Y5	Anti Bait CoIP	16724116
种属内	Tcf7l2	Q924A0	Hic1	Mus musculus	Q9R1Y5	Anti Tag CoIP	16724116

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W010995	2,5-Dimethylcelecoxib	Inhibitor	99.57%	否
HY-N3628	Coronarin A	Inhibitor	≥98.0%	否
HY-RS14310	TCF7L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Tcf7l2	NCBI	NCBI:6934

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box Gene

关于 Tcf7l2

功能概要

Tcf7l2 基因产物(31)

Tcf7l2 蛋白互作信息

直系同源

热门区域

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Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box Gene

关于 Tcf7l2

功能概要

Tcf7l2 基因产物(31)

Tcf7l2 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z