2. Gene
  3. F2RL2 - coagulation factor II thrombin receptor like 2 Gene

F2RL2 - coagulation factor II thrombin receptor like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凝血因子 II 凝血酶受体样 2

种属: Homo sapiens

同用名: PAR3; PAR-3

基因 ID: 2151 | 基因类型: protein coding

关于 F2RL2

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,615,482-76,623,403 (from NCBI)

This gene has 2 transcripts (splice variants), 262 orthologues and 16 paralogues. Biased expression in gall bladder (RPKM 4.3), endometrium (RPKM 1.5) and 10 other tissues.

功能概要

该基因编码蛋白酶激活受体 (PAR) 家族的成员，该家族是七个跨膜 G 蛋白偶联细胞表面受体家族的一个亚家族。编码的蛋白质在凝血酶介导的蛋白酶激活受体家族成员 PAR4 的切割和激活中充当辅助因子。编码的蛋白质在止血和血栓形成中起着重要作用。交替剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the Protease-activated Receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the Protease-activated Receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

F2RL2 基因产物(2)

mRNA Protein Name
NM_004101.4 NP_004092.1 proteinase-activated receptor 3 isoform 1 precursor
NM_001256566.2 NP_001243495.1 proteinase-activated receptor 3 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16458856 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
16458856 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

F2RL2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (112 - 358)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

proteinase-activated receptor 3

Coagulation factor II receptor-like 2 (protease-actovated receptor 3)

protease-activated receptor 3

thrombin receptor-like 2

F2RL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
F2RL2 O00254 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Thrombosis

Thrombosis Of Blood Vessel
Achondroplasia

Achondroplastic Dwarfism

ACH

Osteosclerosis Congenita

Achondroplastic Physique

Chondrodystrophia

Dwarf, Achondroplastic

Achondroplastic Short Stature

Congenital Osteosclerosis
Thrombophlebitis Migrans
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04637 F2RL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04638 F2rl2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04639 F2rl2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris F2RL2 VGNC VGNC:53169
Macaca mulatta F2RL2 VGNC VGNC:72465
Rattus norvegicus F2RL2 RGD RGD:620871
Mus musculus F2RL2 MGD MGI:1298208
Bos taurus F2RL2 VGNC VGNC:28685
Felis catus F2RL2 VGNC VGNC:102198
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