Mgat2 - mannoside acetylglucosaminyltransferase 2 Gene

中文名称：甘露糖苷乙酰氨基葡萄糖转移酶 2

种属: Mus musculus

同用名: GNT2; CDGS2; GNT-II; GLCNACTII

关于 Mgat2

功能概要

该基因编码的蛋白可启动 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase 活性。通过天冬酰胺作用于蛋白质 N-连接糖基化的上游或内部。预测位于高尔基体。预测在高尔基体膜中有活性。以多种结构表达，包括消化系统；颅骨;外皮系统；感觉器官；和端脑。用于研究 IIa 型糖基化先天性疾病。该基因的人类直系同源物与 IIa 型糖基化先天性疾病有关。与人 MGAT2（α-1,6-甘露糖基糖蛋白 2-β-N-乙酰氨基葡萄糖转移酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within protein N-linked glycosylation via asparagine. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Used to study congenital disorder of glycosylation type IIa. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIa. Orthologous to human MGAT2 (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]