FAP - fibroblast activation protein alpha Gene

中文名称：成纤维细胞活化蛋白α

种属: Homo sapiens

同用名: FAPA; SIMP; DPPIV; FAPalpha

基因 ID: 2191 | 基因类型: protein coding

关于 FAP

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,170,684-162,243,445 (from NCBI)

This gene has 13 transcripts (splice variants), 127 orthologues and 6 paralogues. Biased expression in endometrium (RPKM 7.5), gall bladder (RPKM 5.1) and 11 other tissues.

功能概要

由该基因编码的蛋白质是属于丝氨酸蛋白酶家族的同型二聚体整合膜明胶酶。它在上皮癌的反应性基质成纤维细胞、愈合伤口的肉芽组织以及骨和软组织肉瘤的恶性细胞中选择性表达。这种蛋白质被认为在发育、组织修复和上皮癌发生过程中参与成纤维细胞生长或上皮-间充质相互作用的控制。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 4 月]

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

FAP 基因产物(2)

mRNA	Protein	Name
NM_001291807.3	NP_001278736.1	prolyl endopeptidase FAP isoform 2
NM_004460.5	NP_004451.2	prolyl endopeptidase FAP isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables dipeptidyl-peptidase activity	IDA IDA: 通过直接分析推断	10593948	GOA
enables endopeptidase activity	IDA IDA: 通过直接分析推断	17317851	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9065413	GOA
enables integrin binding	IPI IPI: 通过物理相互作用推断	10455171	GOA
enables peptidase activity	IDA IDA: 通过直接分析推断	9688278	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	17317851	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16651416	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	10455171	GOA
enables serine-type endopeptidase activity	IDA IDA: 通过直接分析推断	10593948	GOA
enables serine-type peptidase activity	IDA IDA: 通过直接分析推断	16651416	GOA
enables serine-type peptidase activity	IMP IMP: 通过突变表型推断	9065413	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endothelial cell migration	IDA IDA: 通过直接分析推断	16651416	GOA
involved in negative regulation of extracellular matrix disassembly	IDA IDA: 通过直接分析推断	16651416	GOA
involved in negative regulation of extracellular matrix organization	IDA IDA: 通过直接分析推断	10455171	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	10455171	GOA
involved in proteolysis	IMP IMP: 通过突变表型推断	9065413	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: 通过直接分析推断	10593948	GOA
involved in regulation of collagen catabolic process	IDA IDA: 通过直接分析推断	10455171	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	17317851	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	9065413	GOA
part of peptidase complex	IMP IMP: 通过突变表型推断	9065413	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10593948	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAP 蛋白结构

DPPIV_N

Peptidase_S9

0
200
400
600
760 a.a.

蛋白主名

其他名称

prolyl endopeptidase FAP

170 kDa melanoma membrane-bound gelatinase

FAP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FAP	Q12884	VIP	Homo sapiens	P01282	Protease Assay	21314817
种属内	FAP	Q12884	GCG	Homo sapiens	P01275	Protease Assay	21314817

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FAP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72659	FAP Protein, Human (HEK293, His)	Q12884-1 (L26-D760)	≥95%
HY-P77521	FAP Protein, Human (Biotinylated, HEK293, His)	Q12884-1 (L26-D760)	≥95%
HY-P78121	FAP Protein, Human (Biotinylated, HEK293, His-Avi)	Q12884-1 (L26-D760)	≥95%

关联疾病

疾病名称

别名

Breast Ductal Carcinoma

Ductal Breast Carcinoma	Duct Carcinoma
Carcinoma, Ductal	Mammary Ductal Carcinoma
Ductal Carcinoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Glioma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	纯度	Phase
HY-P3392	Zilganersen	/	Phase 3
HY-137331	FAPI-46	98.57%	Phase 2
HY-147057	FAP-2286	99.54%	Phase 1
HY-147057A	FAP-2286 acetate	/	Phase 1

目录号	产品名	作用方式	纯度	Phase
HY-P99269	Sibrotuzumab		≥95.0%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101801	Ac-Gly-BoroPro		≥98.0%	否
HY-128643	FAPI-4		98.42%	否
HY-145983	Suc-Gly-Pro-AMC		99.16%	否
HY-153552A	NH2-UAMC1110 TFA	Inhibitor	99.89%	否
HY-145938	OncoFAP		99.77%	否
HY-147173	FAPI-74		99.84%	否
HY-47979A	FAP-IN-2 TFA	Inhibitor	99.92%	否
HY-P10131	3BP-3940		99.96%	否
HY-136641	NOTA-FAPI	Inhibitor	99.26%	否
HY-47979	FAP-IN-2	Inhibitor	99.82%	否
HY-164316	FT-FAPI-12_9		95.29%	否
HY-139401	FAPI-34		99.67%	否
HY-128642	FAPI-2		98.94%	否
HY-164364A	DOTAGA.(SA.FAPi)2 TFA	Inhibitor	96.81%	否
HY-P3392A	Zilganersen sodium	Inhibitor	91.43%	否
HY-125366	ARI-3099		/	否
HY-P3441A	3BP-4089 TFA		99.64%	否
HY-D2363	DOTA.SA.FAPi TFA	Inhibitor	99.26%	否
HY-164725	FAPI-mFS	Inhibitor	99.78%	否
HY-164316A	FT-FAPI-12_9 TFA		99.48%	否
HY-146182	FSDD3I		/	否
HY-158326	FAP-IN-4	Inhibitor	/	否
HY-148361	Fluorogen binding modulator-1		/	否
HY-146181	FSDD1I		/	否
HY-P3441	3BP-4089		/	否
HY-149860	FAP-IN-1	Inhibitor	/	否
HY-103323	Fas C-Terminal Tripeptide	Inhibitor	/	否
HY-161262	SB03178	Inhibitor	/	否
HY-161074	PNT6555		96.55%	否
HY-D2281	[99mTc]Tc-6–1		/	否
HY-128642A	FAPI-2 TFA		98.05%	否
HY-146180	FSDD0I		/	否
HY-164364B	DOTAGA.(SA.FAPi)2 analogue TFA	Inhibitor	/	否
HY-163079	AlF-PD-FAPI		/	否
HY-168278	Ga-CY03	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FAP	RGD	RGD:621253
Bos taurus	FAP	VGNC	VGNC:28862
Canis familiaris	FAP	VGNC	VGNC:40727
Felis catus	FAP	VGNC	VGNC:62146
Macaca mulatta	FAP	VGNC	VGNC:72613
Mus musculus	FAP	MGD	MGI:109608
Macaca fascicularis	FAP	NCBI	NCBI:102134935
Others	FAP	NCBI

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沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAP - fibroblast activation protein alpha Gene

关于 FAP

功能概要

FAP 基因产物(2)

FAP 蛋白结构

FAP 蛋白互作信息

重组 FAP 蛋白

关联疾病

直系同源

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FAP - fibroblast activation protein alpha Gene

关于 FAP

功能概要

FAP 基因产物(2)

FAP 蛋白结构

FAP 蛋白互作信息

重组 FAP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z