2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation Metabolic Enzyme/Protease
  3. Radionuclide-Drug Conjugates (RDCs) FAP Prolyl Endopeptidase (PREP)
  4. DOTA.SA.FAPi TFA

DOTA.SA.FAPi TFA 是一种双功能性 DATA5m 和 DOTA 螯合剂，由方酸 (squaric acid) 和 UAMC1110 组成。DOTA.SA.FAPi TFA 抑制\成纤维细胞活化蛋白 (FAP)，IC50 为 0.9 nM。DOTA.SA.FAPi TFA 靶向蛋白酶 PREP，IC50 为 5.4 μM。DOTA.SA.FAPi TFA 用 68Ga 标记后可用作 PET 示踪剂，用于癌症研究。

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Custom Peptide Synthesis

DOTA.SA.FAPi TFA Chemical Structure

DOTA.SA.FAPi TFA Chemical Structure

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规格 价格 是否有货 数量
100 μg ￥2100
In-stock
500 μg ￥5300
In-stock
1 mg 现货 询价
5 mg   询价  
10 mg   询价  

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Customer Review

DOTA.SA.FAPi TFA 相关抗体

Top Publications Citing Use of Products

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

查看所有亚型
RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator, which is composed of the squaric acid and UAMC1110. DOTA.SA.FAPi TFA inhibits fibroblast activation protein (FAP) with an IC50 of 0.9 nM. DOTA.SA.FAPi TFA targets protease PREP with an IC50 of 5.4 μM. DOTA.SA.FAPi TFA can be used a PET tracer, when labeled with 68Ga, and used for research about cancer[1].

IC50 & Target

RDC Bifunctional Chelator

 

分子量

1069.98

Formula

C45H56F5N11O14
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

DOTA.SA.FAPi TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA.SA.FAPiRadionuclide-Drug Conjugates (RDCs)FAPProlyl Endopeptidase (PREP)Fibroblast activation protein prolyl oligopeptidasePOPHT-29colorectal cancerbreast cancerInhibitorinhibitorinhibit

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