2. Gene
  3. Tnfrsf1b - tumor necrosis factor receptor superfamily, member 1b Gene

Tnfrsf1b - tumor necrosis factor receptor superfamily, member 1b Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

基因 ID: 21938 | 基因类型: protein coding

关于 Tnfrsf1b

功能概要

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF Receptor Superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf1b 基因产物(1)

mRNA Protein Name
NM_011610.3 NP_035740.2 tumor necrosis factor receptor superfamily member 1B precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10747083 MGI
enables tumor necrosis factor receptor activity IPI
IPI: 通过物理相互作用推断
1645445 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within RNA destabilization IMP
IMP: 通过突变表型推断
11588035 MGI
involved in aortic valve development IGI
IGI: 通过遗传相互作用推断
26491108 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
9551933 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
7990930 MGI
involved in glial cell-neuron signaling IMP
IMP: 通过突变表型推断
27147664 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
9551933 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
17242187 MGI
involved in negative regulation of cardiac muscle hypertrophy IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in negative regulation of extracellular matrix constituent secretion IGI
IGI: 通过遗传相互作用推断
26491108 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
11588035 MGI
involved in negative regulation of neuroinflammatory response IMP
IMP: 通过突变表型推断
27147664 MGI
involved in positive regulation of apoptotic process involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in positive regulation of myelination IMP
IMP: 通过突变表型推断
27147664 MGI
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
27147664 MGI
involved in pulmonary valve development IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in regulation of T cell cytokine production IMP
IMP: 通过突变表型推断
28052249 MGI
involved in regulation of T cell proliferation IMP
IMP: 通过突变表型推断
28052249 MGI
involved in regulation of cytokine production involved in immune response IGI
IGI: 通过遗传相互作用推断
28052249 MGI
involved in regulation of myelination IGI
IGI: 通过遗传相互作用推断
28052249 MGI
involved in regulation of neuroinflammatory response IGI
IGI: 通过遗传相互作用推断
28052249 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
10747083 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
17010968 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 1B

TNF receptor beta chain

TNF-RII

TNFR-II

p75 TNFR

p80 TNF-alpha receptor

tumor necrosis factor receptor 2

tumor necrosis factor receptor type II

重组 Tnfrsf1b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70516 TNF RII/TNFRSF1B Protein, Mouse (HEK293, His) P25119/NP_035740.2 (V23-G258) ≥95%
HY-P72420 TNF RII/TNFRSF1B Protein, Mouse (HEK293, His-Avi) Q545P4 (V23-G258) ≥95%
HY-P76108 TNF RII/TNFRSF1B Protein, Mouse (HEK293, Fc) P25119 (M1-G258) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14811 TNFRSF1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990994 Emunkitug Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfrsf1b NCBI NCBI:7133
Macaca mulatta Tnfrsf1b NCBI NCBI:715454
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