MED19 - mediator complex subunit 19 Gene

中文名称：调解复合体亚基 19

种属: Homo sapiens

同用名: LCMR1; DT2P1G7; MED19AS

基因 ID: 219541 | 基因类型: protein coding

关于 MED19

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,703,709-57,712,215 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 5.0) and 25 other tissues.

功能概要

该基因编码的蛋白质是 Mediator 复合体的一个亚基，它与基因特异性调节因子结合并为基础 RNA 聚合酶 II 转录机制提供支持。该基因与多种癌症的生长有关，抑制其表达可抑制这些癌症的生长和扩散。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of Cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MED19 基因产物(2)

mRNA	Protein	Name
NM_001317078.4	NP_001304007.2	mediator of RNA polymerase II transcription subunit 19 isoform 1
NM_153450.4	NP_703151.3	mediator of RNA polymerase II transcription subunit 19 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14576168	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of core mediator complex	IPI IPI: 通过物理相互作用推断	24882805	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24882805	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MED19 蛋白结构

Med19

0
100
194 a.a.

蛋白主名

其他名称

mediator of RNA polymerase II transcription subunit 19

lung cancer metastasis-related protein 1

MED19 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	14576168
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	14638676
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	15175163
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	21729782
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
种属内	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lipodystrophy, Familial Partial, Type 5

FPLD5	Cidec-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 5	Cidec-Related Fpld
Familial Partial Lipodystrophy Associated With Cidec Mutations	Lipodystrophy, Familial Partial, Associated With Cidec Mutations
Lipodystrophy, Familial Partial, 5

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08290	MED19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MED19	VGNC	VGNC:31356
Mus musculus	MED19	MGD	MGI:1914234
Macaca mulatta	MED19	VGNC	VGNC:74615
Rattus norvegicus	MED19	RGD	RGD:1311926
Felis catus	MED19	VGNC	VGNC:103134
Canis familiaris	MED19	VGNC	VGNC:43128

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MED19 - mediator complex subunit 19 Gene

关于 MED19

功能概要

MED19 基因产物(2)

MED19 蛋白结构

MED19 蛋白互作信息

关联疾病

直系同源

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MED19 - mediator complex subunit 19 Gene

关于 MED19

功能概要

MED19 基因产物(2)

MED19 蛋白结构

MED19 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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