UNC5B - unc-5 netrin receptor B Gene

中文名称：unc-5 netrin 受体 B

种属: Homo sapiens

同用名: UNC5H2; p53RDL1

关于 UNC5B

功能概要

该基因编码 netrin 受体家族的一个成员。这种特殊的蛋白质介导 netrin-1 的排斥作用，是一种血管 netrin 受体。这种编码的蛋白质也属于一组称为依赖性受体 (DpRs) 的蛋白质，它们参与促凋亡和抗凋亡过程。许多 DpR 参与胚胎发生和癌症进展。已经描述了该基因的两个选择性剪接的转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in Cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]