2. Gene
  3. Tshr - thyroid stimulating hormone receptor Gene

Tshr - thyroid stimulating hormone receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：促甲状腺激素受体

种属: Mus musculus

同用名: hyt; pet; hypothroid

基因 ID: 22095 | 基因类型: protein coding

关于 Tshr

Chromosome 12: 91,351,337-91,516,582 forward strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 66 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues.

功能概要

该基因编码的蛋白可启动促甲状腺激素受体活性。参与冷诱导产热的正调节。在几个过程的上游或内部起作用，包括成人运动行为；多巴胺能神经元分化；和内耳发育。位于质膜。在膀胱中表达；肾血管系统；甲状腺;和甲状腺叶。用于研究先天性甲状腺功能减退症。该基因的人类直系同源物与格雷夫斯病有关；心肌病;先天性非甲状腺肿性甲状腺功能减退症 1；和二尖瓣脱垂。与人类 TSHR（促甲状腺激素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tshr 基因产物(2)

mRNA Protein Name
NM_011648.5 NP_035778.3 thyrotropin receptor isoform 1 precursor
NM_001113404.1 NP_001106875.1 thyrotropin receptor isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables thyroid-stimulating hormone receptor activity IDA
IDA: 通过直接分析推断
7789342 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
9300691 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11440271 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: 通过突变表型推断
11530227 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: 通过突变表型推断
10575115 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: 通过突变表型推断
10575115 MGI
acts upstream of or within inner ear receptor cell development IMP
IMP: 通过突变表型推断
10575115 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: 通过突变表型推断
10575115 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
18559984 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: 通过突变表型推断
11530227 MGI
acts upstream of or within regulation of locomotion IMP
IMP: 通过突变表型推断
11530227 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
7789342 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tshr 蛋白结构

LRR_RI

LRR_RI: sd00033 (53 - 76)

LRR_5

LRR_5: cl37855 (64 - 220)

LRR_RI

LRR_RI: sd00033 (77 - 101)

LRR_RI

LRR_RI: sd00033 (102 - 126)

LRR_RI

LRR_RI: sd00033 (127 - 151)

LRR_RI

LRR_RI: sd00033 (152 - 176)

LRR_RI

LRR_RI: sd00033 (180 - 200)

LRR_RI

LRR_RI: sd00033 (201 - 225)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (414 - 688)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (415 - 441)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (448 - 473)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (493 - 523)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (535 - 557)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (577 - 606)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (616 - 646)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (656 - 681)

  • 0
  • 200
  • 400
  • 600
  • 764 a.a.
蛋白主名 其他名称

thyrotropin receptor

TSH-R

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-107916 Thyrotropin / 否
Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12381 ML224 Antagonist 99.18% 否
HY-114116 ML-109 Agonist 99.12% 否
HY-129995A TSHR antagonist S37a Antagonist 98.00% 否
HY-158100 SYD5115 Antagonist 99.69% 否
HY-150210 FSHR agonist 1 Agonist 98.48% 否
HY-100271 Org41841 Agonist 99.77% 否
HY-18286 NCGC00229600 Antagonist 99.67% 否
HY-122974 VA-K-14 hydrochloride Antagonist 98.20% 否
HY-124867 D3-βArr Modulator 99.49% 否
HY-114918 MS438 Agonist 99.85% 否
HY-114994 MS437 Activator / 否
HY-129995 TSHR antagonist S37b Inhibitor 99.06% 否
HY-169054 NCATS-SM4420 / 否
HY-RS15145 TSHR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15146 Tshr Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15147 Tshr Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tshr NCBI NCBI:7253
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