2. Gene
  3. ALDH3B1 - aldehyde dehydrogenase 3 family member B1 Gene

ALDH3B1 - aldehyde dehydrogenase 3 family member B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙醛脱氢酶 3 家族成员 B1

种属: Homo sapiens

同用名: ALDH4; ALDH7

基因 ID: 221 | 基因类型: protein coding

关于 ALDH3B1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:68,008,547-68,029,276 (from NCBI)

This gene has 9 transcripts (splice variants), 355 orthologues and 17 paralogues. Broad expression in lung (RPKM 26.2), bone marrow (RPKM 14.3) and 17 other tissues.

功能概要

该基因编码醛脱氢酶蛋白家族的一个成员。醛脱氢酶是同工酶家族，可能在酒精代谢和脂质过氧化产生的醛的解毒中发挥重要作用。编码的蛋白质能够在体外氧化长链脂肪醛，并可能在保护免受氧化应激方面发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 2 月]

This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

ALDH3B1 基因产物(5)

mRNA Protein Name
NM_000694.4 NP_000685.1 aldehyde dehydrogenase family 3 member B1 isoform a
NM_001030010.3 NP_001025181.1 aldehyde dehydrogenase family 3 member B1 isoform b
NM_001161473.3 NP_001154945.1 aldehyde dehydrogenase family 3 member B1 isoform a
NM_001290058.2 NP_001276987.1 aldehyde dehydrogenase family 3 member B1 isoform c
NM_001290059.2 NP_001276988.1 aldehyde dehydrogenase family 3 member B1 isoform d
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
IDA: 通过直接分析推断
20699116 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within aldehyde catabolic process IDA
IDA: 通过直接分析推断
20699116 GOA
acts upstream of or within cellular response to oxidative stress IDA
IDA: 通过直接分析推断
20699116 GOA
acts upstream of or within response to oxidative stress IDA
IDA: 通过直接分析推断
20699116 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
20699116 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALDH3B1 蛋白结构

Aldedh

Aldedh: Aldehyde dehydrogenase family (52 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
蛋白主名 其他名称

aldehyde dehydrogenase family 3 member B1

aldehyde dehydrogenase 3B1

ALDH3B1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ALDH3B1 P43353 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra ALDH3B1 P43353 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Y2H Prey Pooling
25416956
Intra ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Validated Y2H
25416956
Intra ALDH3B1 P43353 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra ALDH3B1 P43353 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra ALDH3B1 P43353 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra ALDH3B1 P43353 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra ALDH3B1 P43353 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra ALDH3B1 P43353 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra ALDH3B1 P43353 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra ALDH3B1 P43353 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra ALDH3B1 P43353 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Paranoid Schizophrenia

Chronic Paranoid Schizophrenia

Paranoid Type Schizophrenia

Paranoid Type Schizophrenia Subchronic State

Paraphrenia - Late

Paraphrenic Schizophrenia

Schizophrenia, Paranoid
Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome

SLS

Faldh Deficiency

Fatty Aldehyde Dehydrogenase Deficiency

Fatty Acid Alcohol Oxidoreductase Deficiency

Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia

Sjogren Larsson Syndrome

Fatty Alcohol:Nad+ Oxidoreductase Deficiency

Sjogren-Larsson'S Syndrome

Fadh Deficiency

Fao Deficiency

Congenital Icthyosis Mental Retardation Spasticity Syndrome

Ichthyosis Oligophrenia Syndrome

Sjoegren-Larsson Syndrome
Paraneoplastic Polyneuropathy
Epilepsy, Pyridoxine-Dependent

Pyridoxine-Dependent Epilepsy

PDE

Pyridoxine Dependency With Seizures

Vitamin B6-Dependent Seizures

EPD

Aasa Dehydrogenase Deficiency

Antiquitin Deficiency

Pyridoxine Dependency

Glutamate Decarboxylase Deficiency

Pyridoxine-Dependent Seizures

Deficiency Of Glutamate Decarboxylase
Hyperprolinemia

Proline Oxidase Deficiency

Hyperprolinemia Type 1

Proline Hydrogenase Deficiency

Prolinemia

Pyrroline Carboxylate Dehydrogenase Deficiency

Pyrroline-5-Carboxylate Dehydrogenase Deficiency

Proline Dehydrogenase Deficiency

Hyperprolinemia Type 2
Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria

Ssadh Deficiency

Gamma-Hydroxybutyric Aciduria

Gaba Metabolic Defect

SSADHD

Ssadh

Succinate-Semialdehyde Dehydrogenase Deficiency

Gamma-Hydroxybutyricaciduria

4-Hydroxybutyricaciduria

Gamma-Hydroxybutyric Acidemia

Succinate Semialdehyde Dehydrogenase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ALDH3B1 VGNC VGNC:56255
Macaca mulatta ALDH3B1 VGNC VGNC:69789
Mus musculus ALDH3B1 MGD MGI:1914939
Rattus norvegicus ALDH3B1 RGD RGD:1359546
Canis familiaris ALDH3B1 VGNC VGNC:51840
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