2. Gene
  3. SPATA13 - spermatogenesis associated 13 Gene

SPATA13 - spermatogenesis associated 13 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：精子发生相关 13

种属: Homo sapiens

同用名: ASEF2; ARHGEF29

基因 ID: 221178 | 基因类型: protein coding

关于 SPATA13

Cytogenetic location: 13q12.12 Genomic coordinates (GRCh38): 13:23,979,802-24,307,069 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 22.0), lymph node (RPKM 7.6) and 25 other tissues.

功能概要

启用胍基核苷酸交换因子活性和相同的蛋白质结合活性。参与细胞迁移；质膜有界细胞投射组件；和细胞迁移的调节。位于多个细胞成分中，包括 filopodium；片状足；和荷叶边膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPATA13 基因产物(6)

mRNA Protein Name
NM_001166271.3 NP_001159743.1 spermatogenesis-associated protein 13 isoform 1
NM_001286792.2 NP_001273721.1 spermatogenesis-associated protein 13 isoform 3
NM_001286793.2 NP_001273722.1 spermatogenesis-associated protein 13 isoform 4
NM_001286794.2 NP_001273723.1 spermatogenesis-associated protein 13 isoform 5
NM_001286795.2 NP_001273724.1 spermatogenesis-associated protein 13 isoform 6
NM_153023.4 NP_694568.1 spermatogenesis-associated protein 13 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
19934221 GOA
enables guanyl-nucleotide exchange factor activity IMP
IMP: 通过突变表型推断
17145773 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17145773 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17145773 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IMP
IMP: 通过突变表型推断
17145773 GOA
involved in filopodium assembly IMP
IMP: 通过突变表型推断
17145773 GOA
involved in lamellipodium assembly IMP
IMP: 通过突变表型推断
17599059 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
17599059 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19151759 GOA
located in filopodium IDA
IDA: 通过直接分析推断
17599059 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
17599059 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
19151759 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPATA13 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (154 - 201)

RhoGEF

RhoGEF: RhoGEF domain (244 - 423)

PH

PH: PH domain (457 - 555)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 652 a.a.
蛋白主名 其他名称

spermatogenesis-associated protein 13

APC-stimulated guanine nucleotide exchange factor 2

SPATA13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SPATA13 Q96N96 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
SPATA13 Q96N96 YWHAE Homo sapiens P62258
Anti Tag CoIP
33961781
种属内
SPATA13 Q96N96 YWHAE Homo sapiens P62258
Anti Tag CoIP
28514442
种属内
SPATA13 Q96N96 APC Homo sapiens P25054
IF
17145773
种属内
SPATA13 Q96N96 APC Homo sapiens P25054
Anti Bait CoIP
17145773
种属内
SPATA13 Q96N96 APC Homo sapiens P25054
Anti Bait CoIP
17599059
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Optic Atrophy 3, Autosomal Dominant

Optic Atrophy 3

OPA3

Autosomal Dominant Optic Atrophy And Cataract

Optic Atrophy And Cataract, Autosomal Dominant

Autosomal Dominant Optic Atrophy Type 3

Optic Atrophy 3 With Cataract

Opa3, Autosomal Dominant

Adoac

Optic Atrophy, Cataract, And Neurologic Disorder

Autosomal Dominant Optic Atrophy 3

Optic Atrophy Type 3

Optic Atrophy 3 Autosomal Dominant

Atrophy, Optic, Type 3, Autosomal Dominant

3-Methylglutaconic Aciduria Type 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13636 SPATA13 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPATA13 MGD MGI:104838
Rattus norvegicus SPATA13 RGD RGD:1307364
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