1. Gene
  2. MRAS - muscle RAS oncogene homolog Gene

MRAS - muscle RAS oncogene homolog Gene

中文名称:肌肉 RAS 致癌基因同系物

种属: Homo sapiens

同用名: NS11; M-RAs; RRAS3; R-RAS3

基因 ID: 22808 | 基因类型: protein coding

关于 MRAS

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,347,648-138,405,535 (from NCBI)

This gene has 11 transcripts (splice variants), 241 orthologues, 35 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues.

功能概要

该基因编码小 GTP 酶 Ras 家族的成员。这些膜相关蛋白在包括细胞生长和分化在内的多个过程中起着信号转导的作用,而 Ras 信号的失调与多种类型的癌症有关。编码的蛋白质可能在肿瘤坏死因子-α 和 MAP 激酶信号通路中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 11 月]

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of Cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

MRAS 基因产物(6)

mRNA Protein Name
NM_001085049.3 NP_001078518.1 ras-related protein M-Ras isoform 1 precursor
NM_001252090.2 NP_001239019.1 ras-related protein M-Ras isoform 1 precursor
NM_001252091.1 NP_001239020.1 ras-related protein M-Ras isoform 2 precursor
NM_001252092.2 NP_001239021.1 ras-related protein M-Ras isoform 2 precursor
NM_001252093.2 NP_001239022.1 ras-related protein M-Ras isoform 2 precursor
NM_012219.4 NP_036351.3 ras-related protein M-Ras isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP-dependent protein binding IPI
IPI: 通过物理相互作用推断
10934204 GOA
enables GTPase activity IMP
IMP: 通过突变表型推断
28289718 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25137548 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Ras protein signal transduction IMP
IMP: 通过突变表型推断
28289718 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MRAS 蛋白结构

Ras

Ras: Ras family (15 - 176)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

ras-related protein M-Ras

muscle and microspikes RAS

MRAS 抗体

目录号 产品名 应用 反应物种
HY-P83335 MRAS Antibody (YA3080) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Noonan Syndrome 11

NS11

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

Cardiomyopathy, Hypertrophic

Cardiomyopathy Hypertrophic Obstructive

Cardiomyopathy, Hypertrophic, Familial

Idiopathic Myocardial Hypertrophy

Idiopathic Hypertrophic Cardiomyopathy

Obstructive Idiopathic Hypertrophic Cardiomyopathy

Obstructive Cardiomyopathy

Idiopathic Hypertrophic Subaortic Stenosis

Muscular Subaortic Stenosis

Hypertrophic Obstructive Subaortic Stenosis

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome

Multiple Lentigines Syndrome

Moynahan Syndrome

Cardiomyopathic Lentiginosis

Progressive Cardiomyopathic Lentiginosis

Cardio-Cutaneous Syndrome

Lentiginosis Profusa

Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome

Generalized Lentiginosis

Gorlin Syndrome Ii

Lentiginosis Profusa Syndrome

Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes

Diffuse Lentiginosis

Nsml

Familial Multiple Lentigines Syndrome

Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type

Progressive Cardiomyopathic Lentiginosis Syndrome

Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Neurofibromatosis-Noonan Syndrome

NFNS

Neurofibromatosis Type 1

Neurofibromatosis With Noonan Phenotype

Nf1

Von Recklinghausen Disease

Neurofibromatosis Type 1-Noonan Syndrome

Noonan Neurofibromatosis Syndrome

Recklinghausen'S Disease

Noonan-Neurofibromatosis Syndrome

Fibromatosis Multiple Non Ossifying

Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots

Jaffe Campanacci Syndrome

Type 1 Neurofibromatosis

Neurofibromatosis 1

Peripheral Neurofibromatosis

Recklinghausen Disease, Nerve

Jaffe-Campanacci Syndrome

Cardiofaciocutaneous Syndrome 1

Cardiofaciocutaneous Syndrome

Cfc Syndrome

Cardio-Facio-Cutaneous Syndrome

CFC1

Cfcs

Cardio-Facial-Cutaneous Syndrome

Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure

Cardiofaciocutaneous Syndrome, Type 1

Costello Syndrome

Faciocutaneoskeletal Syndrome

Fcs Syndrome

Congenital Myopathy With Excess Of Muscle Spindles

CSTLO

CMEMS

Fcss

Myopathy, Congenital, With Excess Of Muscle Spindles

Neurilemmomatosis

Schwannomatosis

Neurofibromatosis Type 3

Nf3

Neurilemmomatosis Congenital Cutaneous

Neurinomatosis

Congenital Cutaneous Neurilemmomatosis

Multiple Neurilemmomas

Multiple Schwannomas

Neurilemmomatosis, Congenital Cutaneous

Schwannomatosis 1

Neurofibromatosis 3

Mixed Central And Peripheral Neurofibromatosis

Nf3 - [Neurofibromatosis Type 3]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MRAS RGD RGD:3111
Macaca mulatta MRAS VGNC VGNC:74924
Bos taurus MRAS VGNC VGNC:31597
Felis catus MRAS VGNC VGNC:68314
Canis familiaris MRAS VGNC VGNC:43358
Mus musculus MRAS MGD MGI:1100856