2. Gene
  3. COPZ1 - COPI coat complex subunit zeta 1 Gene

COPZ1 - COPI coat complex subunit zeta 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：COPI 外套复杂亚基 zeta 1

种属: Homo sapiens

同用名: COPZ; CGI-120; HSPC181; zeta-COP; zeta1-COP

基因 ID: 22818 | 基因类型: protein coding

关于 COPZ1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,325,131-54,351,846 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 49.0), colon (RPKM 30.9) and 25 other tissues.

功能概要

该基因编码细胞质壳蛋白复合物的一个亚基，该复合物参与自噬和细胞内蛋白质运输。外壳蛋白复合物由七个亚基组成，充当外壳蛋白复合物 (COP) I 囊泡的外壳蛋白。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in Autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

COPZ1 基因产物(4)

mRNA Protein Name
NM_001271734.2 NP_001258663.1 coatomer subunit zeta-1 isoform 2
NM_001271735.2 NP_001258664.1 coatomer subunit zeta-1 isoform 3
NM_001271736.2 NP_001258665.1 coatomer subunit zeta-1 isoform 4
NM_016057.3 NP_057141.1 coatomer subunit zeta-1 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intra-Golgi vesicle-mediated transport IDA
IDA: 通过直接分析推断
11056392 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COPI vesicle coat IDA
IDA: 通过直接分析推断
11056392 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COPZ1 蛋白结构

Clat_adaptor_s

Clat_adaptor_s: Clathrin adaptor complex small chain (12 - 151)

  • 0
  • 100
  • 177 a.a.
蛋白主名 其他名称

coatomer subunit zeta-1

coatomer protein complex subunit zeta 1

重组 COPZ1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76847 COPZ1 Protein, Human/Mouse/Rat (His) P61923/NP_001101587.1 (M1-R177) ≥95%

关联疾病

疾病名称 别名
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03034 COPZ1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus COPZ1 MGD MGI:1929063
Macaca mulatta COPZ1 VGNC VGNC:71318
Rattus norvegicus COPZ1 RGD RGD:1306154
Bos taurus COPZ1 VGNC VGNC:27607
Felis catus COPZ1 VGNC VGNC:83540
Others COPZ1 NCBI
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