2. Gene
  3. NTNG1 - netrin G1 Gene

NTNG1 - netrin G1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：netrin G1

种属: Homo sapiens

同用名: Lmnt1

基因 ID: 22854 | 基因类型: protein coding

关于 NTNG1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:107,140,088-107,484,923 (from NCBI)

This gene has 10 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 1.0), kidney (RPKM 0.9) and 14 other tissues.

功能概要

该基因编码一种前原蛋白，该蛋白被加工成含有真核生长因子 (EGF) 样结构域的分泌蛋白。这种蛋白质在神经元发育过程中起到指导轴突生长的作用。该基因的多态性可能与精神分裂症有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 8 月]

This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

NTNG1 基因产物(11)

mRNA Protein Name
NM_001113226.3 NP_001106697.1 netrin-G1 isoform G1a preproprotein
NM_001113228.3 NP_001106699.1 netrin-G1 isoform G1d precursor
NM_001312688.2 NP_001299617.1 netrin-G1 isoform G1n precursor
NM_001330665.2 NP_001317594.1 netrin-G1 isoform 5 precursor
NM_001372166.1 NP_001359095.1 netrin-G1 isoform 6 precursor
NM_001372167.1 NP_001359096.1 netrin-G1 isoform G1a preproprotein
NM_001372168.1 NP_001359097.1 netrin-G1 isoform G1c precursor
NM_001372169.1 NP_001359098.1 netrin-G1 isoform G1d precursor
NM_001372170.1 NP_001359099.1 netrin-G1 isoform G1a preproprotein
NM_001372171.1 NP_001359100.1 netrin-G1 isoform G1c precursor
NM_014917.4 NP_055732.2 netrin-G1 isoform G1c precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
23986473 GOA
enables cell-cell adhesion mediator activity IGI
IGI: 通过遗传相互作用推断
23986473 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14595443 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in synaptic membrane adhesion IGI
IGI: 通过遗传相互作用推断
23986473 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NTNG1 蛋白结构

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (69 - 295)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (297 - 341)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (364 - 417)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (420 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 539 a.a.
蛋白主名 其他名称

netrin-G1

axon guidance molecule

NTNG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NTNG1 Q9Y2I2 NUDT16L1 Homo sapiens Q9BRJ7
Anti Tag CoIP
33961781
种属内
NTNG1 Q9Y2I2 LRRC4C Homo sapiens Q9HCJ2
X-Ray Diffraction
21946559
种属内
NTNG1 Q9Y2I2 LRRC4C Homo sapiens Q9HCJ2
Light Scattering
21946559
种属内
NTNG1 Q9Y2I2 LRRC4 Homo sapiens Q9HBW1
SPR
21946559
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NTNG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71175 NTNG1 Protein, Human (Biotinylated, HEK293, Avi-His) Q9Y2I2 (H29-S409) ≥95%
HY-P71176 NTNG1 Protein, Human (HEK293, His) Q9Y2I2 (H29-S409) ≥95%

关联疾病

疾病名称 别名
Rett Syndrome

Atypical Rett Syndrome

RTT

Rett Disorder

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Preserved Speech Variant

Rett Syndrome, Atypical

Rett'S Disorder

Rett Syndrome Variant

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related
Partial Fetal Alcohol Syndrome
St. Louis Encephalitis

Saint Louis Encephalitis

Neuroinvasive St. Louis Encephalitis Virus Infection

Encephalitis, St. Louis

Neuroinvasive Saint Louis Encephalitis Virus Infection

St. Louis Encephalitis Virus Infection

St. Louis Encephalitis Virus Neuroinvasive Disease

St. Louis Viral Disease

Type C Lethargic Encephalitis

Encephalitis Type C
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Intellectual Developmental Disorder, Autosomal Dominant 41

MRD41

Autosomal Dominant Non-Syndromic Intellectual Disability 41

Mental Retardation, Autosomal Dominant 41

Autosomal Dominant Intellectual Developmental Disorder 41

Autosomal Dominant Mental Retardation 41

Mental Retardation, Autosomal Dominant, Type 41
Glass Syndrome

Chromosome 2q32-Q33 Deletion Syndrome

Satb2-Associated Syndrome

2q33.1 Microdeletion Syndrome

Sas

2q32-Q33 Microdeletion Syndrome

2q32q33 Microdeletion Syndrome

Monosomy 2q32

Monosomy 2q32-Q33

Monosomy 2q32q33

2q32 Deletion Syndrome

Del(2)(Q32)

Del(2)(Q32q33)

GLASS

2q32q33 Microdeletion Syndromes

Satb2 Syndrome

Satb2-Associated Syndrome Due To A Chromosomal Rearrangement

Del(2)(Q33.1)

Monosomy 2q33.1

Satb2-Associated Syndrome Due To A Pathogenic Variant

Satb2-Associated Syndrome Due To A Point Mutation

Satb2 Associated Disorder
Alcohol-Related Birth Defects

Arbd

Alcohol-Related Birth Defect

Alcohol Related Birth Defect

Fetal Alcohol Syndrome
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy

Catecholaminergic Polymorphic Ventricular Tachycardia 1

Ventricular Tachycardia, Catecholaminergic Polymorphic, 1

CPVT1

Ventricular Tachycardia, Stress-Induced Polymorphic

Vtsip

Bidirectional Tachycardia

Stress-Induced Polymorphic Ventricular Tachycardia

Cvpt1

Double Tachycardia Induced By Catecholamines

Malignant Paroxysmal Ventricular Tachycardia

Multifocal Ventricular Premature Beats

Paroxysmal Ventricular Fibrillation

Syncopal Paroxysmal Tachycardia

Syncopal Tachyarythmia

Ventricular Tachycardia Catecholaminergic Polymorphic 1

Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 1

Multifocal Pvcs

Multifocal Premature Ventricular Beats

Paroxysmal Familial Ventricular Fibrillation

Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09625 NTNG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NTNG1 VGNC VGNC:50086
Canis familiaris NTNG1 VGNC VGNC:58321
Felis catus NTNG1 VGNC VGNC:63906
Rattus norvegicus NTNG1 RGD RGD:1563465
Mus musculus NTNG1 MGD MGI:1934028
Macaca mulatta NTNG1 VGNC VGNC:75450
Others NTNG1 NCBI
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