1. Gene
  2. LRRC4 - leucine rich repeat containing 4 Gene

LRRC4 - leucine rich repeat containing 4 Gene

中文名称:含富含亮氨酸的重复序列 4

种属: Homo sapiens

同用名: NAG14; NGL-2

基因 ID: 64101 | 基因类型: protein coding

关于 LRRC4

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,027,071-128,032,128 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues and 22 paralogues. Biased expression in brain (RPKM 14.4), adrenal (RPKM 3.2) and 12 other tissues.

功能概要

该基因在原发性脑肿瘤中显着下调。该基因编码的蛋白质的确切功能尚不清楚。[RefSeq 提供,2008 年 7 月]

This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]

LRRC4 基因产物(1)

mRNA Protein Name
NM_022143.5 NP_071426.1 leucine-rich repeat-containing protein 4 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21946559 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LRRC4 蛋白结构

LRR_5

LRR_5: Leucine rich repeats (6 copies) (89 - 204)

LRR_8

LRR_8: Leucine rich repeat (220 - 278)

I-set

I-set: Immunoglobulin I-set domain (355 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 653 a.a.
蛋白主名 其他名称

leucine-rich repeat-containing protein 4

brain tumor associated protein LRRC4

LRRC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LRRC4 Q9HBW1 NTNG1 Homo sapiens Q9Y2I2
SPR
21946559
种属内
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9 21946559
种属内
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9 21946559
种属内
LRRC4 Q9HBW1 NTNG2 Homo sapiens Q96CW9
SPR
21946559
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LRRC4 VGNC VGNC:74293
Bos taurus LRRC4 VGNC VGNC:31014
Canis familiaris LRRC4 VGNC VGNC:42797
Rattus norvegicus LRRC4 RGD RGD:1560026
Mus musculus LRRC4 MGD MGI:2182081
Felis catus LRRC4 VGNC VGNC:80614
Others LRRC4 NCBI