CLSTN1 - calsyntenin 1 Gene

中文名称：Calsyntenin 1

种属: Homo sapiens

同用名: CST-1; CSTN1; CDHR12; PIK3CD; ALC-ALPHA; XB31alpha; alcalpha1; alcalpha2

关于 CLSTN1

功能概要

该基因是 Calsyntenin 家族的成员，Calsyntenin 家族是钙粘蛋白超家族的一个子集。编码的跨膜蛋白，也称为 alcadein-alpha，被认为与驱动蛋白 1 马达结合，以介导某些类型囊泡的轴突顺行运输。淀粉样前体蛋白 (APP) 通过这些囊泡运输，因此正在研究这种蛋白质，以了解它如何促进阿尔茨海默氏病的潜在机制。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 11 月]

This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]