2. Gene
  3. UBOX5 - U-box domain containing 5 Gene

UBOX5 - U-box domain containing 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 U-box 域 5

种属: Homo sapiens

同用名: UIP5; RNF37; hUIP5; UBCE7IP5

基因 ID: 22888 | 基因类型: protein coding

关于 UBOX5

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,107,573-3,159,865 (from NCBI)

This gene has 3 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues.

功能概要

该基因编码含有蛋白质的 U-box 结构域。编码的蛋白质与 E2 酶相互作用，并可能在泛素化途径中发挥作用。交替剪接导致多个转录本变体。[RefSeq 提供，2012 年 6 月]

This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 Enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

UBOX5 基因产物(3)

mRNA Protein Name
NM_001267584.2 NP_001254513.1 RING finger protein 37 isoform c
NM_014948.4 NP_055763.1 RING finger protein 37 isoform a
NM_199415.3 NP_955447.1 RING finger protein 37 isoform b
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
11274149 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear body IDA
IDA: 通过直接分析推断
11274149 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBOX5 蛋白结构

U-box

U-box: U-box domain (259 - 336)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 541 a.a.
蛋白主名 其他名称

RING finger protein 37

RING-type E3 ubiquitin transferase RNF37

UBOX5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBOX5 O94941 VCP Homo sapiens P55072
Validated Y2H
32296183
种属内
UBOX5 O94941 VCP Homo sapiens P55072
Y2H Array
25416956
种属内
UBOX5 O94941 VCP Homo sapiens P55072
Y2H Array
32296183
种属内
UBOX5 O94941 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
种属内
UBOX5 O94941 TARDBP Homo sapiens Q13148
Y2H Array
32814053
种属内
UBOX5 O94941 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
种属内
UBOX5 O94941 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Y2H Array
31515488
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Validated Y2H
32296183
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Y2H Array
32296183
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Y2H Array
29892012
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Y2H Prey Pooling
32296183
种属内
UBOX5 O94941 MLH1 Homo sapiens P40692
Y2H Pooling
27229929
种属内
UBOX5 O94941 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属内
UBOX5 O94941 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
种属内
UBOX5 O94941 ATXN1 Homo sapiens P54253
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus

Cdi

Pituitary Diabetes Insipidus

Vasopressin Defective Diabetes Insipidus

Vasopressin Deficiency

Central Diabetes Insipidus

Diabetes Insipidus, Neurogenic

Diabetes Insipidus, Primary Central

Diabetes Insipidus, Cranial Type

Diabetes Insipidus Secondary To Vasopressin Deficiency

Diabetes Insipidus, Central

Diabetes Insipidus, Pituitary

NDI

Diabetes Insipidus Cranial Type

Neurogenic Diabetes Insipidus

Primary Central Diabetes Insipidus
Mitochondrial Dna Depletion Syndrome 13

MTDPS13

Fbxl4 Deficiency

Fbxl4-Related Encephalomyopathic Mitochondrial Dna Depletion Syndrome

Mitochondrial Dna Depletion Syndrome 13, Encephalomyopathic Type

Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies

Mtdna Depletion Syndrome, Encephalomyopathic Form With Variable Craniofacial Anomalies

Fbxl4-Related Early-Onset Mitochondrial Encephalopathy

Mitochondrial Dna Depletion Syndrome 13 , Encephalomyopathic Type

Bxl4-Related Early-Onset Mitochondrial Encephalopathy

Encephalomyopathic Mitochondrial Dna Depletion Syndrome-13

Fbxl4-Related Early Onset Mitochondrial Encephalopathy

Mitochondrial Dna Depletion Syndrome, Type 13
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15381 UBOX5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus UBOX5 VGNC VGNC:66780
Macaca mulatta UBOX5 VGNC VGNC:98473
Canis familiaris UBOX5 VGNC VGNC:48083
Bos taurus UBOX5 VGNC VGNC:36612
Rattus norvegicus UBOX5 RGD RGD:1305440
Mus musculus UBOX5 MGD MGI:2154658
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