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  2. ZNF365 - zinc finger protein 365 Gene

ZNF365 - zinc finger protein 365 Gene

中文名称:锌指蛋白 365

种属: Homo sapiens

同用名: UAN; Su48; ZNF365D

基因 ID: 22891 | 基因类型: protein coding

关于 ZNF365

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,374,369-62,480,285 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in brain (RPKM 9.2), esophagus (RPKM 2.1) and 3 other tissues.

功能概要

该基因编码一种锌指蛋白,可能在修复 DNA 损伤和维持基因组稳定性方面发挥作用。 N 末端 C2H2 锌指基序需要与 PARP1 和 MRE11 形成蛋白质复合物,已知它们参与停滞的 DNA 复制叉的重启。该基因的突变可能与乳腺癌易感性有关。[RefSeq 提供,2020 年 3 月]

This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast Cancer susceptibility. [provided by RefSeq, Mar 2020]

ZNF365 基因产物(2)

mRNA Protein Name
NM_014951.3 NP_055766.2 protein ZNF365 isoform A
NM_199450.3 NP_955522.1 protein ZNF365 isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16617106 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16682949 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
16617106 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
16617106 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

protein ZNF365

DISC1-binding zinc-finger protein

ZNF365 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF365 Q70YC5 NDE1 Homo sapiens Q9NXR1
Y2H
16682949
种属内
ZNF365 Q70YC5 NDE1 Homo sapiens Q9NXR1
IF
16682949
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To

Uric Acid Urolithiasis

Uric Acid Nephrolithiasis

UAN

Acute Urate Nephropathy

Urolithiasis, Uric Acid

Urolithiasis, Uric Acid, Susceptibility To

Uric Acid Renal Calculus

Narcolepsy 2

Narcolepsy 2, Susceptibility To

Narcolepsy Without Cataplexy

NRCLP2

Narcolepsy Type 2

Narcolepsy Without Cataplexy And Hypocretin Deficiency

Narcolepsy 1

NRCLP1

Narcoleptic Syndrome 1

Gelineau Disease

Narcolepsy-Cataplexy

Narcolepsy-Cataplexy Syndrome

Narcolepsy, Type 1

Narcolepsy Type 1

Cataplexy

Gélineau'S Syndrome

Narcolepsy With Cataplexy And/Or Hypocretin Deficiency

Mammographic Density
Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi

Urolithiasis
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Vogt-Koyanagi-Harada Disease

Uveomeningoencephalitic Syndrome

Uveomenigitic Syndrome

Vogt-Koyanagi-Harada Syndrome

Harada'S Disease

Vogt-Koyanagi Syndrome

Vkh Disease

Vkh Syndrome

Vkh

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZNF365 VGNC VGNC:55088
Macaca mulatta ZNF365 VGNC VGNC:106123
Canis familiaris ZNF365 VGNC VGNC:48710
Mus musculus ZNF365 MGD MGI:2143676
Felis catus ZNF365 VGNC VGNC:67295