MAST1 - microtubule associated serine/threonine kinase 1 Gene

中文名称：微管相关丝氨酸/苏氨酸激酶 1

种属: Homo sapiens

同用名: SAST; MCCCHCM

关于 MAST1

功能概要

该基因是微管相关丝氨酸/苏氨酸激酶 (MAST) 家族的成员。该基因编码的蛋白质有一个 N 端丝氨酸/苏氨酸激酶结构域，后跟一个突触后密度蛋白 95/discs large/zona occludens-1 (PDZ) 结构域。在小鼠和大鼠中，直系同源蛋白与细胞骨架相关联，并且可以通过其 PDZ 结构域结合 β-2-syntrophin 和神经元一氧化氮合酶 (nNOS) 。在小鼠和大鼠中，这种蛋白质还与中枢神经系统血管内皮细胞中的肌营养不良蛋白和肌营养不良蛋白相关蛋白复合物 (DAPC/UAPC) 共定位。[RefSeq 提供，2017 年 5 月]

This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the Cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]