Cenpe - centromere protein E Gene

中文名称：着丝粒蛋白E

种属: Mus musculus

同用名: Kif10; 312kDa; CENP-E; C530022J18

关于 Cenpe

功能概要

该基因编码的蛋白可启动着丝粒结合活性和蛋白激酶结合活性。参与多个过程，包括纺锤体微管与着丝粒附着的正调控；蛋白激酶活性的正调节；和有丝分裂中期/后期转变的调节。在参与雌性减数分裂 I 的蛋白质稳定性和纺锤体组装的调节上游或调节内起作用。位于着丝粒中。外着丝粒的一部分。在睾丸和胸腺中表达。该基因的人类直系同源物与原发性常染色体隐性遗传性小头畸形 13 相关。与人类 CENPE（着丝粒蛋白 E）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of mitotic metaphase/anaphase transition. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in testis and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Apr 2022]