RAB21 - RAB21, member RAS oncogene family Gene

中文名称：RAB21，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 23011 | 基因类型: protein coding

关于 RAB21

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,754,863-71,800,286 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 68 paralogues. Ubiquitous expression in kidney (RPKM 10.9), adrenal (RPKM 10.2) and 25 other tissues.

功能概要

该基因属于单体 GTPases 的 Rab 家族，参与细胞膜交通的控制。编码的蛋白质通过与整合素 alpha 尾部的关联在整合素的靶向运输中发挥作用。因此，编码的蛋白质参与细胞粘附和迁移的调节。该基因的表达与神经胶质瘤患者的不良预后有关。该基因被肿瘤抑制因子 miR-200b 下调，miRNA-200b 本身在神经胶质瘤组织中下调。[RefSeq 提供，2015 年 11 月]

This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with Integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

RAB21 基因产物(1)

mRNA	Protein	Name
NM_014999.4	NP_055814.1	ras-related protein Rab-21

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	16034420	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	16034420	GOA
enables GTP binding	IMP IMP: 通过突变表型推断	15561770	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	16034420	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16525121	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in anterograde axonal transport	IDA IDA: 通过直接分析推断	22705394	GOA
involved in anterograde axonal transport	IMP IMP: 通过突变表型推断	22705394	GOA
involved in positive regulation of early endosome to late endosome transport	IMP IMP: 通过突变表型推断	15561770	GOA
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: 通过突变表型推断	15561770	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	31455601	GOA
involved in regulation of exocytosis	IDA IDA: 通过直接分析推断	22705394	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi cisterna membrane	IDA IDA: 通过直接分析推断	15561770	GOA
located in cytoplasmic side of early endosome membrane	IDA IDA: 通过直接分析推断	15561770	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: 通过直接分析推断	15561770	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	19745841	GOA
located in vesicle membrane	IDA IDA: 通过直接分析推断	15561770	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB21 蛋白结构

Ras

0
100
200
225 a.a.

蛋白主名

其他名称

ras-related protein Rab-21

GTP-binding protein RAB21

RAB21 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RAB21	Q9UL25	APPL1	Homo sapiens	Q9UKG1	Pull Down	17581628

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Charcot-Marie-Tooth Disease, Type 4b2

Charcot-Marie-Tooth Disease Type 4b2	CMT4B2
Charcot-Marie-Tooth Disease, With Focally Folded Myelin Sheaths, Autosomal Recessive, Type 4b2	Charcot-Marie-Tooth Neuropathy, Type 4b2
Charcot-Marie-Tooth Neuropathy Type 4b2	Autosomal Recessive Charcot-Marie-Tooth Disease With Focally Folded Myelin Sheaths Type 4b2
Cmt 4b2	Charcot Marie Tooth Disease Type 4b2
Charcot-Marie-Tooth Disease 4b2	Charcot-Marie-Tooth Disease Autosomal Recessive With Focally Folded Myelin Sheaths 4b2
Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4b2

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11531	RAB21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RAB21	VGNC	VGNC:33628
Rattus norvegicus	RAB21	RGD	RGD:1303150
Macaca mulatta	RAB21	VGNC	VGNC:100097
Mus musculus	RAB21	MGD	MGI:894308
Canis familiaris	RAB21	VGNC	VGNC:45261

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAB21 - RAB21, member RAS oncogene family Gene

关于 RAB21

功能概要

RAB21 基因产物(1)

RAB21 蛋白结构

RAB21 蛋白互作信息

关联疾病

直系同源

热门区域

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RAB21 - RAB21, member RAS oncogene family Gene

关于 RAB21

功能概要

RAB21 基因产物(1)

RAB21 蛋白结构

RAB21 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z