2. Gene
  3. MYO16 - myosin XVI Gene

MYO16 - myosin XVI Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌球蛋白 XVI

种属: Homo sapiens

同用名: MYR8; MYAP3; NYAP3; Myo16b; PPP1R107

基因 ID: 23026 | 基因类型: protein coding

关于 MYO16

Cytogenetic location: 13q33.3 Genomic coordinates (GRCh38): 13:108,495,716-109,208,005 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 43 paralogues. Biased expression in brain (RPKM 1.6), fat (RPKM 1.1) and 8 other tissues.

功能概要

该基因编码一种非常规的肌球蛋白。已提议编码的蛋白质充当丝氨酸/苏氨酸磷酸酶-1 靶向或调节亚基。对大鼠细胞系的研究表明，这种蛋白质可以调节细胞周期进程。该基因中的一个变体可能与精神分裂症的易感性有关，并且已经在人类精神分裂症患者的额叶皮质中观察到该基因的表达升高。[RefSeq 提供，2017 年 3 月]

This gene encodes an unconventional Myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]

MYO16 基因产物(2)

mRNA Protein Name
NM_001198950.3 NP_001185879.1 unconventional myosin-XVI isoform 1
NM_015011.3 NP_055826.1 unconventional myosin-XVI isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25902260 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleoplasm IDA
IDA: 通过直接分析推断
17029291 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
17029291 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYO16 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (67 - 156)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (205 - 285)

Myosin_head

Myosin_head: Myosin head (motor domain) (404 - 1133)

NYAP_N

NYAP_N: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter (1208 - 1576)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1858 a.a.
蛋白主名 其他名称

unconventional myosin-XVI

MYO16 variant protein

关联疾病

疾病名称 别名
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08933 MYO16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MYO16 VGNC VGNC:75042
Mus musculus MYO16 MGD MGI:2685951
Bos taurus MYO16 VGNC VGNC:53825
Canis familiaris MYO16 VGNC VGNC:43556
Rattus norvegicus MYO16 RGD RGD:621561
Felis catus MYO16 VGNC VGNC:102258
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