CLASP2 - cytoplasmic linker associated protein 2 Gene

中文名称：细胞质接头相关蛋白 2

种属: Homo sapiens

基因 ID: 23122 | 基因类型: protein coding

关于 CLASP2

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:33,496,245-33,718,254 (from NCBI)

This gene has 27 transcripts (splice variants), 226 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.5), adrenal (RPKM 10.5) and 22 other tissues.

功能概要

启用细胞骨架蛋白结合活性； dystroglycan 结合活性；和蛋白酪氨酸激酶结合活性。参与多个过程，包括微管细胞骨架组织；细胞外基质组织的正向调节；和超分子纤维组织的调控。位于多个细胞成分中，包括基底皮层；皮层微管加端；和荷叶边膜。与粘着斑共定位；动粒；和微管细胞骨架。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including microtubule Cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; cortical microtubule plus-end; and ruffle membrane. Colocalizes with focal adhesion; kinetochore; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

CLASP2 基因产物(53)

mRNA	Protein	Name
NM_001207044.3	NP_001193973.1	CLIP-associating protein 2 isoform 2
NM_001365627.1	NP_001352556.1	CLIP-associating protein 2 isoform 3
NM_001365628.1	NP_001352557.1	CLIP-associating protein 2 isoform 4
NM_001365629.1	NP_001352558.1	CLIP-associating protein 2 isoform 5
NM_001365630.1	NP_001352559.1	CLIP-associating protein 2 isoform 6
NM_001365631.1	NP_001352560.1	CLIP-associating protein 2 isoform 7
NM_001365632.1	NP_001352561.1	CLIP-associating protein 2 isoform 8
NM_001365633.1	NP_001352562.1	CLIP-associating protein 2 isoform 9
NM_001365634.1	NP_001352563.1	CLIP-associating protein 2 isoform 10
NM_001375694.1	NP_001362623.1	CLIP-associating protein 2 isoform 11
NM_001375697.1	NP_001362626.1	CLIP-associating protein 2 isoform 12
NM_001375700.1	NP_001362629.1	CLIP-associating protein 2 isoform 13
NM_001375701.1	NP_001362630.1	CLIP-associating protein 2 isoform 14
NM_001375703.1	NP_001362632.1	CLIP-associating protein 2 isoform 16
NM_001375705.1	NP_001362634.1	CLIP-associating protein 2 isoform 15
NM_001375713.1	NP_001362642.1	CLIP-associating protein 2 isoform 17
NM_001375715.1	NP_001362644.1	CLIP-associating protein 2 isoform 18
NM_001375716.1	NP_001362645.1	CLIP-associating protein 2 isoform 19
NM_001375718.1	NP_001362647.1	CLIP-associating protein 2 isoform 20
NM_001375720.1	NP_001362649.1	CLIP-associating protein 2 isoform 21
NM_001400405.1	NP_001387334.1	CLIP-associating protein 2 isoform 22
NM_001400406.1	NP_001387335.1	CLIP-associating protein 2 isoform 23
NM_001400407.1	NP_001387336.1	CLIP-associating protein 2 isoform 24
NM_001400408.1	NP_001387337.1	CLIP-associating protein 2 isoform 25
NM_001400409.1	NP_001387338.1	CLIP-associating protein 2 isoform 26
NM_001400410.1	NP_001387339.1	CLIP-associating protein 2 isoform 27
NM_001400411.1	NP_001387340.1	CLIP-associating protein 2 isoform 28
NM_001400412.1	NP_001387341.1	CLIP-associating protein 2 isoform 29
NM_001400413.1	NP_001387342.1	CLIP-associating protein 2 isoform 30
NM_001400414.1	NP_001387343.1	CLIP-associating protein 2 isoform 31
NM_001400415.1	NP_001387344.1	CLIP-associating protein 2 isoform 32
NM_001400416.1	NP_001387345.1	CLIP-associating protein 2 isoform 33
NM_001400417.1	NP_001387346.1	CLIP-associating protein 2 isoform 33
NM_001400418.1	NP_001387347.1	CLIP-associating protein 2 isoform 34
NM_001400419.1	NP_001387348.1	CLIP-associating protein 2 isoform 35
NM_001400420.1	NP_001387349.1	CLIP-associating protein 2 isoform 36
NM_001400421.1	NP_001387350.1	CLIP-associating protein 2 isoform 37
NM_001400422.1	NP_001387351.1	CLIP-associating protein 2 isoform 38
NM_001400423.1	NP_001387352.1	CLIP-associating protein 2 isoform 39
NM_001400424.1	NP_001387353.1	CLIP-associating protein 2 isoform 40
NM_001400425.1	NP_001387354.1	CLIP-associating protein 2 isoform 41
NM_001400427.1	NP_001387356.1	CLIP-associating protein 2 isoform 42
NM_001400428.1	NP_001387357.1	CLIP-associating protein 2 isoform 43
NM_001400429.1	NP_001387358.1	CLIP-associating protein 2 isoform 44
NM_001400430.1	NP_001387359.1	CLIP-associating protein 2 isoform 45
NM_001400431.1	NP_001387360.1	CLIP-associating protein 2 isoform 46
NM_001400432.1	NP_001387361.1	CLIP-associating protein 2 isoform 47
NM_001400433.1	NP_001387362.1	CLIP-associating protein 2 isoform 48
NM_001400434.1	NP_001387363.1	CLIP-associating protein 2 isoform 49
NM_001400435.1	NP_001387364.1	CLIP-associating protein 2 isoform 50
NM_001400436.1	NP_001387365.1	CLIP-associating protein 2 isoform 51
NM_001400437.1	NP_001387366.1	CLIP-associating protein 2 isoform 52
NM_015097.3	NP_055912.2	CLIP-associating protein 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin filament binding	IDA IDA: 通过直接分析推断	24520051	GOA
enables dystroglycan binding	IPI IPI: 通过物理相互作用推断	23940118	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	24520051	GOA
enables microtubule plus-end binding	IDA IDA: 通过直接分析推断	11290329	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11290329	GOA
enables protein tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	24520051	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	24859005	GOA
involved in exit from mitosis	IMP IMP: 通过突变表型推断	16866869	GOA
involved in microtubule anchoring	IMP IMP: 通过突变表型推断	17543864	GOA
involved in microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	24859005	GOA
involved in microtubule nucleation	IMP IMP: 通过突变表型推断	17543864	GOA
involved in microtubule organizing center organization	IMP IMP: 通过突变表型推断	17543864	GOA
involved in mitotic spindle organization	IMP IMP: 通过突变表型推断	16866869	GOA
involved in negative regulation of focal adhesion assembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in negative regulation of wound healing, spreading of epidermal cells	IMP IMP: 通过突变表型推断	24859005	GOA
involved in platelet-derived growth factor receptor-beta signaling pathway	IDA IDA: 通过直接分析推断	24520051	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP IMP: 通过突变表型推断	23940118	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	24859005	GOA
involved in positive regulation of exocytosis	IMP IMP: 通过突变表型推断	24859005	GOA
involved in positive regulation of extracellular matrix disassembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in presynaptic cytoskeleton organization	IDA IDA: 通过直接分析推断	23035100	GOA
involved in presynaptic cytoskeleton organization	IMP IMP: 通过突变表型推断	23035100	GOA
involved in protein localization to plasma membrane	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: 通过直接分析推断	24520051	GOA
involved in regulation of axon extension	IDA IDA: 通过直接分析推断	24520051	GOA
involved in regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of gastrulation	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of microtubule polymerization	IDA IDA: 通过直接分析推断	24520051	GOA
involved in regulation of microtubule polymerization or depolymerization	IMP IMP: 通过突变表型推断	11290329	GOA
involved in regulation of microtubule-based process	IMP IMP: 通过突变表型推断	20937854	GOA
involved in vesicle targeting	IMP IMP: 通过突变表型推断	24859005	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	11290329	GOA
located in axonal growth cone	IDA IDA: 通过直接分析推断	24520051	GOA
located in basal cortex	IDA IDA: 通过直接分析推断	23940118	GOA
located in cell cortex	IDA IDA: 通过直接分析推断	17113391	GOA
located in cell leading edge	IDA IDA: 通过直接分析推断	24859005	GOA
located in cortical microtubule plus-end	IDA IDA: 通过直接分析推断	24520051	GOA
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	11290329	GOA
colocalizes with focal adhesion	IDA IDA: 通过直接分析推断	24859005	GOA
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	23035100	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	23035100	GOA
colocalizes with kinetochore	IMP IMP: 通过突变表型推断	16866869	GOA
colocalizes with microtubule	IDA IDA: 通过直接分析推断	24859005	GOA
located in microtubule	IDA IDA: 通过直接分析推断	17543864	GOA
colocalizes with mitotic spindle	IMP IMP: 通过突变表型推断	16866869	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	20937854	GOA
located in ruffle membrane	IDA IDA: 通过直接分析推断	20937854	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	17543864	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLASP2 蛋白结构

CLASP_N

0
300
600
900
1200
1514 a.a.

蛋白主名

其他名称

CLIP-associating protein 2

CLIP-associating protein CLASP2

CLASP2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLASP2	O75122	MAPRE1	Homo sapiens	Q15691	Pull Down	19632184
种属内	CLASP2	O75122	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
种属内	CLASP2	O75122	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属间	CLASP2	O75122	Clip2	Rattus norvegicus	O55156	Pull Down	11290329
种属间	CLASP2	O75122	Clip2	Rattus norvegicus	O55156	Anti Tag CoIP	11290329

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P0227	SHU 9119		99.95%	否
HY-RS02745	CLASP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CLASP2	MGD	MGI:1923749
Canis familiaris	CLASP2	VGNC	VGNC:39295
Macaca mulatta	CLASP2	VGNC	VGNC:84201
Bos taurus	CLASP2	VGNC	VGNC:27390
Felis catus	CLASP2	VGNC	VGNC:60917
Rattus norvegicus	CLASP2	RGD	RGD:619789

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLASP2 - cytoplasmic linker associated protein 2 Gene

关于 CLASP2

功能概要

CLASP2 基因产物(53)

CLASP2 蛋白结构

CLASP2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CLASP2 - cytoplasmic linker associated protein 2 Gene

关于 CLASP2

功能概要

CLASP2 基因产物(53)

CLASP2 蛋白结构

CLASP2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z