SNX13 - sorting nexin 13 Gene

中文名称：排序 nexin 13

种属: Homo sapiens

同用名: RGS-PX1

关于 SNX13

功能概要

该基因编码含有 PHOX 结构域和 RGS 结构域的蛋白质，属于分选连接蛋白 (SNX) 家族和 G 蛋白信号 (RGS) 家族的调节因子。 PHOX 结构域是磷酸肌醇结合结构域，SNX 家族成员参与细胞内运输。 RGS 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白。这种蛋白质的 RGS 结构域与 G alpha (s) 相互作用，加速其 GTP 水解，并减弱 G alpha (s) 介导的信号。这种蛋白质的过度表达会延迟表皮生长因子受体的溶酶体降解。由于其双功能作用，该蛋白可能将异源三聚体 G 蛋白信号转导和囊泡运输联系起来。[RefSeq 提供，2008 年 7 月]

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008]