MAPK8IP3 - mitogen-activated protein kinase 8 interacting protein 3 Gene

中文名称：丝裂原活化蛋白激酶 8 相互作用蛋白 3

种属: Homo sapiens

同用名: syd; JIP3; SYD2; JIP-3; JSAP1; NEDBA

关于 MAPK8IP3

功能概要

由该基因编码的蛋白质与果蝇 syd 基因的产物具有相似性，后者是驱动蛋白 I 与轴突货物功能相互作用所必需的。对小鼠中相似基因的研究表明，这种蛋白质可能与 JNK 信号通路的许多蛋白激酶相互作用并调节其活性，因此在神经元细胞中起支架蛋白的作用。该基因的线虫对应物被发现可能通过整合 JNK 信号和驱动蛋白 1 转运来调节突触小泡转运。已经描述了该基因的几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of Kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]