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  2. STAB1 - stabilin 1 Gene

STAB1 - stabilin 1 Gene

中文名称:稳定蛋白 1

种属: Homo sapiens

同用名: FEX1; FEEL1; FEEL-1; FELE-1; SCARH2; STAB-1; CLEVER-1

基因 ID: 23166 | 基因类型: protein coding

关于 STAB1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,495,338-52,524,495 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 2 paralogues. Broad expression in spleen (RPKM 55.7), placenta (RPKM 32.7) and 21 other tissues.

功能概要

该基因编码一种大的跨膜受体蛋白,该蛋白可能在血管生成、淋巴细胞归巢、细胞粘附或受体清除中发挥作用。该蛋白质包含 7 个成束蛋白、16 个表皮生长因子 (EGF) 样结构域和 2 个层粘连蛋白型 EGF 样结构域以及一个 C 型凝集素样透明质酸结合连接模块。该蛋白主要在肝、脾和淋巴结的窦状内皮细胞上表达。该受体已被证明可以内吞配体,例如低密度脂蛋白、革兰氏阳性和革兰氏阴性细菌,以及高级糖基化终产物。支持其作为清道夫受体的可能作用,该蛋白质在质膜和早期内体之间快速循环。[RefSeq 提供,2008 年 7 月]

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

STAB1 基因产物(1)

mRNA Protein Name
NM_015136.3 NP_055951.2 stabilin-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables low-density lipoprotein particle binding IDA
IDA: 通过直接分析推断
12077138 GOA
enables low-density lipoprotein particle receptor activity IDA
IDA: 通过直接分析推断
12077138 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16357325 GOA
enables scavenger receptor activity IDA
IDA: 通过直接分析推断
12077138 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell signaling IDA
IDA: 通过直接分析推断
12077138 GOA
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
12077138 GOA
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
12077138 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12077138 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STAB1 蛋白结构

Fasciclin

Fasciclin: Fasciclin domain (384 - 490)

Fasciclin

Fasciclin: Fasciclin domain (518 - 643)

EGF_3

EGF_3: EGF domain (913 - 945)

EGF_3

EGF_3: EGF domain (951 - 987)

Fasciclin

Fasciclin: Fasciclin domain (1000 - 1120)

Fasciclin

Fasciclin: Fasciclin domain (1140 - 1230)

EGF_3

EGF_3: EGF domain (1459 - 1495)

EGF_3

EGF_3: EGF domain (1501 - 1536)

Fasciclin

Fasciclin: Fasciclin domain (1606 - 1710)

Fasciclin

Fasciclin: Fasciclin domain (1737 - 1866)

EGF_3

EGF_3: EGF domain (2095 - 2130)

Xlink

Xlink: Extracellular link domain (2208 - 2300)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2570 a.a.
蛋白主名 其他名称

stabilin-1

MS-1 antigen

STAB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STAB1 Q9NY15 FN1 Homo sapiens P02751
Y2H
34968453
种属内
STAB1 Q9NY15 FN1 Homo sapiens P02751 34968453
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Histiocytosis

Chronic Histiocytosis X

Hand Schuller Christian Disease

Hand-Schüller-Christian Disease

Histiocytic Syndrome

Histiocytosis, Langerhans-Cell

Chronic Kidney Disease

Chronic Renal Disease

Chronic Kidney Failure

Ckd

Chronic Renal Failure

Kidney Failure, Chronic

Chronic Renal Failure Syndrome

Crf

Renal Failure - Chronic

Renal Failure Chronic

Chronic Kidney Diseases

Chronic Kidney Disease Stage 5

Ckd - [Chronic Kidney Disease]

Crf - [Chronic Renal Failure]

Chronic Kidney Impairment

Chronic Renal Impairment

Chronic Kidney Shutdown

Chronic Hypoxic Kidney Failure

Chronic Kidney Collapse

Chronic Renal Insufficiency

Chronic Kidney Toxaemia

Chronic Kidney Hypofunction

Chronic Renal Suppression

Chronic Renal Failure, Stage 5

Ckd - [Chronic Kidney Disease] Stage 5

End Stage Kidney Failure

End Stage Renal Failure

End Stage Kidney Disease

End Stage Renal Disease

End Stage Chronic Renal Failure

Esrf - [End Stage Renal Failure]

Esrd - [End Stage Renal Diseases]

Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus STAB1 MGD MGI:2178742
Rattus norvegicus STAB1 RGD RGD:2324745
Bos taurus STAB1 VGNC VGNC:35348
Macaca mulatta STAB1 VGNC VGNC:77956
Canis familiaris STAB1 VGNC VGNC:54368
Felis catus STAB1 VGNC VGNC:65739