1. Gene
  2. RGL1 - ral guanine nucleotide dissociation stimulator like 1 Gene

RGL1 - ral guanine nucleotide dissociation stimulator like 1 Gene

中文名称:ral 鸟嘌呤核苷酸解离刺激物 1

种属: Homo sapiens

同用名: RGL

基因 ID: 23179 | 基因类型: protein coding

关于 RGL1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,636,109-183,928,532 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 23.7), brain (RPKM 15.5) and 22 other tissues.

功能概要

预计参与催化活性的调节。预测位于胞质溶胶中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL1 基因产物(5)

mRNA Protein Name
NM_001297669.3 NP_001284598.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297670.3 NP_001284599.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297671.3 NP_001284600.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 3
NM_001297672.3 NP_001284601.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 4
NM_015149.6 NP_055964.3 ral guanine nucleotide dissociation stimulator-like 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RGL1 蛋白结构

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (69 - 173)

RasGEF

RasGEF: RasGEF domain (230 - 450)

RA

RA: Ras association (RalGDS/AF-6) domain (648 - 734)

  • 0
  • 200
  • 400
  • 600
  • 768 a.a.
蛋白主名 其他名称

ral guanine nucleotide dissociation stimulator-like 1

ralGDS-like 1

RGL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RGL1 Q9NZL6 HRAS Homo sapiens P01112 20936779
种属内
RGL1 Q9NZL6 HRAS Homo sapiens P01112 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nutritional Optic Neuropathy
Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Toxic Optic Neuropathy
Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RGL1 MGD MGI:107484
Rattus norvegicus RGL1 RGD RGD:1308947
Felis catus RGL1 VGNC VGNC:64590
Bos taurus RGL1 VGNC VGNC:33903
Macaca mulatta RGL1 VGNC VGNC:76868
Canis familiaris RGL1 VGNC VGNC:45512